Publication Name	World Journal of Clinical Oncology
Manuscript ID	21494
Country	Israel

Received	2015-07-17 08:47
Peer-Review Started	2015-07-17 17:26
To Make the First Decision	2015-10-27 11:01
Return for Revision	2015-11-03 17:31
Revised	2015-11-15 15:43
Second Decision	2016-02-15 17:12
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-02-24 14:21
Articles in Press	2016-02-24 14:22
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-26 15:12
Publish the Manuscript Online	2016-04-07 11:01

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Immunology
Manuscript Type	Review
Article Title	Role of the microbiome in non-gastrointestinal cancers
Manuscript Source	Invited Manuscript
All Author List	Meirav Pevsner-Fischer, Timur Tuganbaev, Mariska Meijer, Sheng-Hong Zhang, Zhi-Rong Zeng, Min-Hu Chen and Eran Elinav
Funding Agency and Grant Number
Corresponding Author	Eran Elinav, MD, PhD, Department of Immunology, Weizmann Institute of Science, 100 Herzl Street, Rehovot 7610001, Israel. eran.elinav@weizmann.ac.il
Key Words	Microbiome; Non-gastrointestinal cancers; Carcinogenesis; Dysbiosis; Microbial agent
Core Tip	“The forgotten organ”, the human microbiome, comprises a community of microorganisms that colonizes various sites of the human body. A complex host-micro-biome relationship has emerged in which many functions became codependent. This coupling becomes evident when disruption in the microbiome composition, termed dysbiosis, is mirrored by the development of pathologies in the host. Among the most serious consequences of dysbiosis, is the development of cancer. As many as 20% of total cancers worldwide are caused by a microbial agent. Here, we will review the available evidences implicating microbiome involvement in the development and progression of non-gastrointestinal cancers. Developing a system-wide approach to cancer-microbiome studies will be crucial in understanding how microbiome influences carcinogenesis, and may enable to employ microbiome-targeting approaches as part of cancer treatment.
Publish Date	2016-04-07 11:01
Citation	Pevsner-Fischer M, Tuganbaev T, Meijer M, Zhang SH, Zeng ZR, Chen MH, Elinav E. Role of the microbiome in non-gastrointestinal cancers. World J Clin Oncol 2016; 7(2): 200-213
URL	http://www.wjgnet.com/2218-4333/full/v7/i2/200.htm
DOI	http://dx.doi.org/10.5306/wjco.v7.i2.200

Full Article (PDF)	WJCO-7-200.pdf
Full Article (Word)	WJCO-7-200.doc
Manuscript File	21494-Review.docx
Answering Reviewers	21494-Answering reviewers.pdf
Audio Core Tip	21494-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	21494-Conflict-of-interest statement.pdf
Copyright License Agreement	21494-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21494-Language certificate.pdf
Peer-review Report	21494-Peer-review(s).pdf
Scientific Misconduct Check	21494-Scientific misconduct check.pdf
Scientific Editor Work List	21494-Scientific editor work list.pdf