| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Human urokinase-type plasminogen activator gene-modified bone marrow-derived mesenchymal stem cells attenuate liver fibrosis in rats by down-regulating the Wnt signaling pathway
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Zhi-Gang Ma, Xiao-Dan Lv, Ling-Ling Zhan, Lan Chen, Qi-Yuan Zou, Ji-Qiao Xiang, Jiao-Li Qin, Wei-Wei Zhang, Zhao-Jing Zeng, Hui Jin, Hai-Xing Jiang and Xiao-Ping Lv |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81460114 |
| Natural Science Foundation of Guangxi Zhuang Autonomous Region |
1355005-3-2 |
| Natural Science Foundation of Guangxi Zhuang Autonomous Region |
2012GXNSFAA053143 |
| Chinese Traditional Medicine Science Foundation of Guangxi Zhuang Autonomous Region |
GZPT1238 |
| Science Foundation of Guangxi Department of Education |
201203YB036 |
| Science Foundation of Guangxi Department of Education |
2013LX031 |
|
| Corresponding Author |
Xiao-Ping Lv, Professor, Department of Gastroenterology, the First Affiliated Hospital of Guangxi Medical University, No. 6 Shuangyong Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. lxxp58@hotmail.com |
| Key Words |
Bone marrow-derived mesenchymal stem cells; Liver fibrosis; Urokinase plasminogen activator; Wnt signaling pathway |
| Core Tip |
It has been confirmed that urokinase plasminogen activator (uPA) has a protective effect in liver fibrosis. Bone marrow-derived mesenchymal stem cells (BMSCs) have been discovered to provide effective therapy for liver fibrosis. Therefore, the present study was designed to investigate the therapeutic effects of uPA gene modified BMSCs in a rat model of CCl4-induced liver fibrosis, and the impact on the Wnt signaling pathway which is involved in the pathogenesis of liver fibrosis. uPA gene modified BMSCs can suppress liver fibrosis and ameliorate liver function. Furthermore, it also resulted in down-regulation of molecules of the Wnt signaling pathway and may be a new approach to treating liver fibrosis. |
| Publish Date |
2016-01-23 17:08 |
| Citation |
Ma ZG, Lv XD, Zhan LL, Chen L, Zou QY, Xiang JQ, Qin JL, Zhang WW, Zeng ZJ, Jin H, Jiang HX, Lv XP. Human urokinase-type plasminogen activator gene-modified bone marrow-derived mesenchymal stem cells attenuate liver fibrosis in rats by down-regulating the Wnt signaling pathway. World J Gastroenterol 2016; 22(6): 2092-2103 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i6/2092.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i6.2092 |
