Publication Name	World Journal of Gastroenterology
Manuscript ID	21546
Country	Italy

Received	2015-07-28 14:11
Peer-Review Started	2015-07-30 09:05
To Make the First Decision	2015-09-09 17:32
Return for Revision	2015-09-15 17:49
Revised	2015-09-26 22:21
Second Decision	2015-12-01 10:40
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-12-14 15:58
Articles in Press	2015-12-14 15:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-07 15:34
Publish the Manuscript Online	2016-01-20 16:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness
Manuscript Source	Invited Manuscript
All Author List	Cristina Stasi and Stefano Milani
Funding Agency and Grant Number
Corresponding Author	Cristina Stasi, MD, PhD, Department of Experimental and Clinical Medicine, Largo Brambilla 3, University of Florence, 50141 Firenze, Italy. cristina.stasi@gmail.com
Key Words	Stiffness; Serum markers; Liver fibrosis; Hepatitis C virus; Public health
Core Tip	The results of several studies have shown that non-invasive methods are becoming increasingly precise in predicting non-significant and advanced liver fibrosis, thus reducing the need for liver biopsy in a relevant number of patients. However, when both serum markers and transient elastography values fall, liver biopsy may be still needed. Recently, the guidelines for the screening, care, and treatment of hepatitis C virus infected patients produced by the World Health Organization suggested that the AST-to-platelet ratio index or FIB-4 test could be used for the evaluation of liver fibrosis rather than other, more expensive non-invasive tests in a resource-limited setting.
Publish Date	2016-01-20 16:55
Citation	Stasi C, Milani S. Non-invasive assessment of liver fibrosis: Between prediction/prevention of outcomes and cost-effectiveness. World J Gastroenterol 2016; 22(4): 1711-1720
URL	http://www.wjgnet.com/1007-9327/full/v22/i4/1711.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i4.1711

Full Article (PDF)	WJG-22-1711.pdf
Full Article (Word)	WJG-22-1711.doc
Manuscript File	21546-Review.doc
Answering Reviewers	21546-Answering reviewers.pdf
Audio Core Tip	21546-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21546-Conflict-of-interest statement.pdf
Copyright License Agreement	21546-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21546-Language certificate.pdf
Peer-review Report	21546-Peer-review(s).pdf
Scientific Misconduct Check	21546-Scientific misconduct check.pdf
Scientific Editor Work List	21546-Scientific editor work list.pdf