Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	21571
Country	Greece

Received	2015-07-20 08:31
Peer-Review Started	2015-07-23 11:35
To Make the First Decision	2015-10-08 16:07
Return for Revision	2015-10-13 14:29
Revised	2015-11-13 00:00
Second Decision	2015-11-27 15:58
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-12-08 15:20
Articles in Press	2015-12-08 15:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-22 09:39
Publish the Manuscript Online	2016-01-28 14:57

ISSN	2219-2808 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Pediatrics
Manuscript Type	Minireviews
Article Title	Clinical spectrum of primary ciliary dyskinesia in childhood
Manuscript Source	Invited Manuscript
All Author List	Andrew Fretzayas and Maria Moustaki
Funding Agency and Grant Number
Corresponding Author	Andrew Fretzayas, MD, PhD, Emeritus Professor of Pediatrics, 3rd Department of Pediatrics, “Attikon” University Hospital, Athens University, School of Medicine, 1 Rimini Str, Haidari, 12462 Athens, Greece. mar.moustaki@gmail.com
Key Words	Primary ciliary dyskinesia; Kartagener’s syndrome; Immotile cilia; Heterotaxy; Respiratory tract
Core Tip	The clinical spectrum of primary ciliary dyskinesia (PCD) has been recently better understood through the evolution of electron microscopy techniques, molecular genetics and imaging of the respiratory tract. Herein, we highlight the clinical profile of the disease from infancy to adolescence, focusing on clinical studies of children with a laboratory confirmed diagnosis of PCD. Additionally, the currently recognized associations of the type of ciliary ultrastructure defects and involved mutated genes with the clinical spectrum of the disease are presented. This information is of interest for the paediatrician in order to conduct a timely investigation of children with symptoms suggestive of PCD.
Publish Date	2016-01-28 14:57
Citation	Fretzayas A, Moustaki M. Clinical spectrum of primary ciliary dyskinesia in childhood. World J Clin Pediatr 2016; 5(1): 57-62
URL	http://www.wjgnet.com/2219-2808/full/v5/i1/57.htm
DOI	http://dx.doi.org/10.5409/wjcp.v5.i1.57

Full Article (PDF)	WJCP-5-57.pdf
Full Article (Word)	WJCP-5-57.doc
Manuscript File	21571-Review.doc
Answering Reviewers	21571-Answering reviewers.pdf
Audio Core Tip	21571-Audio core tip.wav
Conflict-of-Interest Disclosure Form	21571-Conflict-of-interest statement.pdf
Copyright License Agreement	21571-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21571-Language certificate.pdf
Peer-review Report	21571-Peer-review(s).pdf
Scientific Misconduct Check	21571-Scientific misconduct check.pdf
Scientific Editor Work List	21571-Scientific editor work list.pdf