Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	21596
Country	United States

Received	2015-07-21 13:26
Peer-Review Started	2015-07-30 11:25
To Make the First Decision	2015-09-14 17:41
Return for Revision	2015-09-15 14:30
Revised	2015-10-09 11:53
Second Decision	2015-11-23 17:59
Accepted by Journal Editor-in-Chief	2015-11-23 23:22
Accepted by Executive Editor-in-Chief	2015-12-04 16:17
Articles in Press	2015-12-04 16:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-20 10:58
Publish the Manuscript Online	2016-01-29 11:06

ISSN	2150-5349 (online)
Open Access	Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors
Manuscript Source	Unsolicited Manuscript
All Author List	Edy Soffer, Leonardo Rodríguez, Patricia Rodriguez, Beatriz Gómez, Manoel G Neto and Michael D Crowell
Funding Agency and Grant Number
Corresponding Author	Edy Soffer, MD, Division of Gastroen­terology, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, HCC One, Los Angeles, CA 90033, United States. esoffer@usc.edu
Key Words	Refractory gastroesophageal reflux disease; Gastroesophageal reflux; Electrical stimulation; Lower esophageal sphincter; Proton pump inhibitors
Core Tip	Proton pump Inhibitors (PPI) are the main medical therapy for gastroesophageal reflux disease (GERD). However, 30%-40% of patients are unsatisfied with PPI therapy. Traditional antireflux surgery is effective but is associated with adverse effects and its numbers are declining, resulting in an unmet need for alternative therapies. Electrical stimulation therapy (EST) of the LES has been shown to significantly improve GERD symptoms and esophageal acid exposure in patients with GERD. The current study shows that patients who respond to PPI but are concerned about the drugs, as well as those with incomplete response to PPI respond equally to EST of the LES.
Publish Date	2016-01-29 11:06
Citation	Soffer E, Rodríguez L, Rodriguez P, Gómez B, Neto MG, Crowell MD. Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors. World J Gastrointest Pharmacol Ther 2016; 7(1): 145-155
URL	http://www.wjgnet.com/2150-5349/full/v7/i1/145.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v7.i1.145

Full Article (PDF)	WJGPT-7-145.pdf
Full Article (Word)	WJGPT-7-145.doc
Manuscript File	21596-Review.docx
Answering Reviewers	21596-Answering reviewers.pdf
Audio Core Tip	21596-Audio core tip.m4a
Biostatistics Review Certificate	21596-Biostatistics statement.pdf
Clinical Trial Registration Statement	21596-Clinical trial registration statement.pdf
Conflict-of-Interest Disclosure Form	21596-Conflict-of-interest statement.pdf
Copyright License Agreement	21596-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	21596-Clinical trial registration statement.pdf
Institutional Review Board Approval Form or Document	21596-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	21596-Language certificate.pdf
Peer-review Report	21596-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21596-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21596-Scientific misconduct check.pdf
Scientific Editor Work List	21596-Scientific editor work list.pdf