Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	21596
Country	United States

Received	2015-07-21 13:26
Peer-Review Started	2015-07-30 11:25
First Decision by Editorial Office Director
Return for Revision	2015-09-15 14:30
Revised	2015-10-09 11:53
Publication Fee Transferred
Second Decision by Editor	2015-11-23 17:59
Second Decision by Editor-in-Chief	2015-11-23 23:22
Final Decision by Editorial Office Director	2015-12-04 16:17
Articles in Press	2015-12-04 16:17
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-20 10:58
Publish the Manuscript Online	2016-01-29 11:06

ISSN	2150-5349 (online)
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Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors
Manuscript Source	Unsolicited Manuscript
All Author List	Edy Soffer, Leonardo Rodríguez, Patricia Rodriguez, Beatriz Gómez, Manoel G Neto and Michael D Crowell
Funding Agency and Grant Number
Corresponding Author	Edy Soffer, MD, Division of Gastroen­terology, Keck School of Medicine, University of Southern California, 1510 San Pablo Street, HCC One, Los Angeles, CA 90033, United States. esoffer@usc.edu
Key Words	Refractory gastroesophageal reflux disease; Gastroesophageal reflux; Electrical stimulation; Lower esophageal sphincter; Proton pump inhibitors
Core Tip	Proton pump Inhibitors (PPI) are the main medical therapy for gastroesophageal reflux disease (GERD). However, 30%-40% of patients are unsatisfied with PPI therapy. Traditional antireflux surgery is effective but is associated with adverse effects and its numbers are declining, resulting in an unmet need for alternative therapies. Electrical stimulation therapy (EST) of the LES has been shown to significantly improve GERD symptoms and esophageal acid exposure in patients with GERD. The current study shows that patients who respond to PPI but are concerned about the drugs, as well as those with incomplete response to PPI respond equally to EST of the LES.
Publish Date	2016-01-29 11:06
Citation	Soffer E, Rodríguez L, Rodriguez P, Gómez B, Neto MG, Crowell MD. Effect of electrical stimulation of the lower esophageal sphincter in gastroesophageal reflux disease patients refractory to proton pump inhibitors. World J Gastrointest Pharmacol Ther 2016; 7(1): 145-155
URL	http://www.wjgnet.com/2150-5349/full/v7/i1/145.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v7.i1.145

Full Article (PDF)	WJGPT-7-145.pdf
Full Article (Word)	WJGPT-7-145.doc