Publication Name	World Journal of Gastroenterology
Manuscript ID	21610
Country	Germany

Received	2015-08-18 11:21
Peer-Review Started	2015-08-18 12:55
To Make the First Decision	2015-11-05 11:03
Return for Revision	2015-11-06 15:51
Revised
Second Decision	2016-01-12 16:28
Accepted by Journal Editor-in-Chief	2016-01-12 17:20
Accepted by Executive Editor-in-Chief	2016-01-30 17:31
Articles in Press	2016-01-30 17:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-06-02 08:44
Publish the Manuscript Online	2016-06-13 09:14

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Last line therapy with sorafenib in colorectal cancer: A retrospective analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Ksenia Martchenko, Irene Schmidtmann, Thomas Thomaidis, Verena Thole, Peter R Galle, Marc Becker, Markus Möhler, Thomas C Wehler and Carl C Schimanski
Funding Agency and Grant Number
Corresponding Author	Carl C Schimanski, Professor, Depart­ment of Internal Medicine, Marienhospital, Martinspfad 72, 64285 Darmstadt, Germany. c.schimanski@marienhospital-darmstadt.de
Key Words	Colorectal cancer; Sorafenib; Regorafenib; Chemotherapy; Last line
Core Tip	In this restrospective analysis we demonstrate that sorafenib monotherapy or in combination with 5-fluorouracil derivates seems to be feasible. Eighty percent of the patients showed stable disease with a median time to progression of 140.5 d and acceptable toxicity profile. In our eyes, the reported overall as well as progression free survival under sorafenib treatment are of clinical and financial interest.
Publish Date	2016-06-13 09:14
Citation	Martchenko K, Schmidtmann I, Thomaidis T, Thole V, Galle PR, Becker M, Möhler M, Wehler TC, Schimanski CC. Last line therapy with sorafenib in colorectal cancer: A retrospective analysis. World J Gastroenterol 2016; 22(23): 5400-5405
URL	http://www.wjgnet.com/1007-9327/full/v22/i23/5400.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i23.5400

Full Article (PDF)	WJG-22-5400.pdf
Full Article (Word)	WJG-22-5400.doc
Manuscript File	21610-Review.doc
Answering Reviewers	21610-Answering reviewers.pdf
Audio Core Tip	21610-Audio core tip.mp3
Biostatistics Review Certificate	21610-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	21610-Conflict-of-interest statement.pdf
Copyright License Agreement	21610-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150818112036.doc
Institutional Review Board Approval Form or Document	Institutional_Review_Board_Statement_20150818112023.doc
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20150818112031.doc
Peer-review Report	21610-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21610-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21610-Scientific misconduct check.pdf
Scientific Editor Work List	21610-Scientific editor work list.pdf