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Articles Published Processes
12/4/2015 3:24:00 PM | Browse: 1157 | Download: 1461
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Received |
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2015-07-26 13:43 |
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Peer-Review Started |
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2015-07-27 10:52 |
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To Make the First Decision |
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2015-09-16 09:15 |
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Return for Revision |
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2015-09-22 18:26 |
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Revised |
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2015-09-28 17:48 |
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Second Decision |
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2015-11-12 14:13 |
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Accepted by Journal Editor-in-Chief |
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2015-11-12 23:11 |
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Accepted by Company Editor-in-Chief |
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2015-11-25 17:27 |
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Articles in Press |
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2015-11-25 17:28 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-12-01 15:27 |
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Publish the Manuscript Online |
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2015-12-04 15:24 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Contributions of transgenic mouse studies on the research of hepatitis B virus and hepatitis C virus-induced hepatocarcinogenesis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Shogo Ohkoshi, Haruka Hirono, Kazuhiko Watanabe, Katsuhiko Hasegawa and Masahiko Yano |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Japan Society for the Promotion of Science (JSPS) |
25461012 (to Shogo Ohkoshi) |
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| Corresponding Author |
Shogo Ohkoshi, MD, PhD, Department of Internal Medicine, School of Life Dentistry at Niigata, the Nippon Dental University, 1-8 Hamaura-Cho, Chuo-ku, Niigata-city 951-8580, Japan. okoshi@ngt.ndu.ac.jp
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| Key Words |
Transgenic mouse; Hepatocarcinogenesis; Hepatitis C virus; Hepatitis B virus X; Hepatitis B virus; Hepatitis C virus core protein; Steatosis |
| Core Tip |
Transgenic technology offers researchers several advantages over in vitro experiments, including the ability to trace the pathogenic effects of viral genes in living organisms. Transgenic mouse studies have provided evidence that the direct action of viral genes, especially the genes encoding hepatitis B virus X and hepatitis C virus core proteins, is involved in hepatocarcinogenesis. However, such results should be considered carefully as transgenic mouse experiments have intrinsic advantages and drawbacks. As such, the results including phenotypes and molecular mechanisms from transgenic mouse studies must always be verified by comparing them to those of human studies for evidence of an association.
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| Publish Date |
2015-12-04 15:24 |
| Citation |
Ohkoshi S, Hirono H, Watanabe K, Hasegawa K, Yano M. Contributions of transgenic mouse studies on the research of hepatitis B virus and hepatitis C virus-induced hepatocarcinogenesis. World J Hepatol 2015; 7(28): 2834-2840 |
| URL |
http://www.wjgnet.com/1948-5182/full/v7/i28/2834.htm |
| DOI |
http://dx.doi.org/10.4254/wjh.v7.i28.2834 |
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