Publication Name	World Journal of Clinical Oncology
Manuscript ID	21677
Country	United States

Received	2015-07-26 13:34
Peer-Review Started	2015-07-27 15:20
To Make the First Decision	2015-09-28 11:54
Return for Revision	2015-09-30 14:53
Revised	2015-10-07 00:00
Second Decision	2015-11-12 14:14
Accepted by Journal Editor-in-Chief	2015-11-14 03:28
Accepted by Executive Editor-in-Chief	2015-11-25 17:29
Articles in Press	2015-11-25 17:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-18 15:03
Publish the Manuscript Online	2016-01-30 17:42

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	Advanced oropharyngeal squamous cell carcinoma: Pathogenesis, treatment, and novel therapeutic approaches
Manuscript Source	Invited Manuscript
All Author List	Paul L Swiecicki, Kelly M Malloy and Francis P Worden
Funding Agency and Grant Number
Corresponding Author	Swiecicki, MD, Division of Hematology/Oncology, Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, 1500 E. Medical Center Drive, SPC 5848, Ann Arbor, MI 48109, United States. pswiecic@med.umich.edu
Key Words	Oropharyngeal cancer; Human papilloma virus; Transoral robotic surgery; Immunotherapy; Metastatic head and neck squamous cell carcinoma
Core Tip	Treatment of oropharyngeal cancer entails a multi-disciplinary approach with concomitant chemoradiation. Given advances in the understanding of human papilloma virus related oropharyngeal cancer, ongoing research is looking at ways to minimize toxicities via de-intensification of therapy. Unfortunately, some patients develop recurrent or metastatic disease. This review discusses the current understanding of the pathogenesis of oropharyngeal cancer and treatment. We also discuss emerging areas of research as it pertains to de-intensification as well novel therapeutics for the management of metastatic disease.
Publish Date	2016-01-30 17:42
Citation	Swiecicki PL, Malloy KM, Worden FP. Advanced oropharyngeal squamous cell carcinoma: Pathogenesis, treatment, and novel therapeutic approaches. World J Clin Oncol 2016; 7(1): 15-26
URL	http://www.wjgnet.com/2218-4333/full/v7/i1/15.htm
DOI	http://dx.doi.org/10.5306/wjco.v7.i1.15

Full Article (PDF)	WJCO-7-15.pdf
Full Article (Word)	WJCO-7-15.doc
Manuscript File	21677-Review.docx
Answering Reviewers	21677-Answering reviewers.pdf
Audio Core Tip	21677-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21677-Conflict-of-interest statement.pdf
Copyright License Agreement	21677-Copyright assignment.pdf
Peer-review Report	21677-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21677-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21677-Scientific misconduct check.pdf
Scientific Editor Work List	21677-Scientific editor work list.pdf