Publication Name	World Journal of Gastroenterology
Manuscript ID	2168
Country	China

Received	2013-02-02 16:21
Peer-Review Started	2013-02-04 22:22
First Decision by Editorial Office Director
Return for Revision	2013-03-19 22:32
Revised
Publication Fee Transferred
Second Decision by Editor	2013-06-19 12:53
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-06-20 00:52
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-23 19:32
Publish the Manuscript Online	2013-08-06 09:19

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses
Manuscript Source	Invited Manuscript
All Author List	Qian-Qian Chen, Li Yan, Chang-Zheng Wang, Wei-Hua Wang, Hui Shi, Bin-Bin Su, Qing-Huan Zeng, Hai-Tao Du and Jun Wan
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81050027
Corresponding Author	Jun Wan, MD, Professor, Department of Gastroenterology, Chinese PLA General Hospital, No. 28, Fu Xing Road, Haidian District, Beijing 100853, China. wanjun301@126.com
Key Words	Mesenchymal stem cells; Transplantation; Inflammatory bowel disease; Inflammatory response; Immunomodulation; Trinitrobenzene sulfonic acid colitis; Therapy
Core Tip	In this study, the following factors were identified: (1) The differentiation of intestinal stem cells in injured gut was determined by detecting Lgr5+ cells; (2) Th1-Th2-Th17-Tregs-related inflammatory and immune cytokine expressions in serum and local intestinal tissues were determined; (3) A Th2 shift and correction of the imbalanced Th17/Tregs were found; (4) Master regulators of Th1, Th2, Th17 and Tregs were detected in bone marrow mesenchymal stem cells -treated trinitrobenzene sulfonic acid-induced colitis; and (5) The passways of Th1-T-bet, Th2-GATA family of transcription factors 3, Th17-retinoid related orphan receptor gamma(t) and Tregs-Foxp3 which serve as important immunoregulators in the correction of immune disorders and enhance the healing of injured intestinal mucosa were identified.
Publish Date	2013-08-06 09:19
Citation	Chen QQ, Yan L, Wang CZ, Wang WH, Shi H, Su BB, Zeng QH, Du HT, Wan J. Mesenchymal stem cells alleviate TNBS-induced colitis by modulating inflammatory and autoimmune responses. World J Gastroenterol 2013; 19(29): 4702-4717
URL	http://www.wjgnet.com/1007-9327/full/v19/i29/4702.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i29.4702

Full Article (PDF)	WJG-19-4702.pdf
Manuscript File	2168-edited.doc
Answering Reviewers	2168-Answering reviewers.pdf
Copyright License Agreement	2168-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2168-Language certificate.pdf
Peer-review Report	2168-Peer review(s).pdf
Scientific Editor Work List	2168-Scientific editor work list.doc