Publication Name	World Journal of Gastroenterology
Manuscript ID	21734
Country	Japan

Received	2015-07-28 17:47
Peer-Review Started	2015-07-30 09:12
To Make the First Decision	2015-09-09 17:32
Return for Revision	2015-09-15 18:31
Revised	2015-09-29 01:42
Second Decision	2015-12-08 13:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-21 13:57
Articles in Press	2015-12-21 13:57
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-23 09:10
Publish the Manuscript Online	2016-01-31 11:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Allergy
Manuscript Type	Review
Article Title	Genomic characterization of esophageal squamous cell carcinoma: Insights from next-generation sequencing
Manuscript Source	Invited Manuscript
All Author List	Yasushi Sasaki, Miyuki Tamura, Ryota Koyama, Takafumi Nakagaki, Yasushi Adachi and Takashi Tokino
Funding Agency and Grant Number	Funding Agency Grant Number MEXT KAKENHI 221S0001
Corresponding Author	Yasushi Sasaki, MD, PhD, Department of Medical Genome Sciences, Research Institute for Frontier Medicine, Sapporo Medical University, S-1, W-17, Chuo-ku, Sapporo 060-8556, Japan. yasushi@sapmed.ac.jp
Key Words	Esophageal squamous cell carcinoma; Next-generation sequencing; Somatic mutation; Driver mutation; Copy number variant
Core Tip	Because targeted therapies have not been implemented in the treatment of esophageal squamous cell carcinoma (ESCC) to date, defining the genetic landscape of ESCC would facilitate the use of targeted therapies. Improvements in molecular profiling tech-nologies have provided new insight into the basic molecular events during carcinogenesis as well as the mechanisms of anti-cancer drug resistance. Our invited review offers a current overview of the somatic genetic alterations in ESCC, emphasizing the recent results of large-scale sequencing efforts using next-generation sequencing technology.
Publish Date	2016-01-31 11:48
Citation	Sasaki Y, Tamura M, Koyama R, Nakagaki T, Adachi Y, Tokino T. Genomic characterization of esophageal squamous cell carcinoma: insights from next-generation sequencing. World J Gastroenterol 2016; 22(7): 2284-2293
URL	http://www.wjgnet.com/1007-9327/full/v22/i7/2284.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i7.2284

Full Article (PDF)	WJG-22-2284.pdf
Full Article (Word)	WJG-22-2284.doc
Manuscript File	21734-Review.docx
Answering Reviewers	21734-Answering reviewers.pdf
Audio Core Tip	21734-Audio core tip.wav
Conflict-of-Interest Disclosure Form	21734-Conflict-of-interest statement.pdf
Copyright License Agreement	21734-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21734-Language certificate.pdf
Peer-review Report	21734-Peer-review(s).pdf
Scientific Misconduct Check	21734-Scientific misconduct check.pdf
Scientific Editor Work List	21734-Scientific editor work list.pdf