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Publication Name World Journal of Gastroenterology
Manuscript ID 21750
Country/Territory China
2015-08-02 12:36
Peer-Review Started
2015-08-03 09:14
To Make the First Decision
2015-09-09 17:33
Return for Revision
2015-09-15 18:56
2015-10-08 23:43
Second Decision
2015-12-08 13:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-12-21 13:58
Articles in Press
2015-12-21 13:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-01-23 09:19
Publish the Manuscript Online
2016-01-31 11:48
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Review
Article Title role of Tim-3 in hepatitis B virus infection: An overview
Manuscript Source Invited Manuscript
All Author List Yuan Liu, Li-fen Gao, Xiao-hong Liang and Chun-hong Ma
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Fund for Outstanding Youth Fund 81425012
National Natural Science Foundation of China 81100203
National Natural Science Foundation of China 81371831
National Natural Science Foundation of China 91129704
Research Fund for the Doctoral Program of Higher Education of China 20110131110034
Corresponding author Chun-hong Ma, PhD, Professor of Immunology, Key Laboratory for Experimental, Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection and Immunology, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan 250012, Shandong province, China. machunhong@sdu.edu.cn
Key Words Tim-3; Hepatitis B virus; Inflammation; Immunity; Liver disease
Core Tip Here, we discuss the current knowledge of the interaction between hepatitis B virus (HBV) and host immunity, addressing the important role of T cell immunoglobulin domain and mucin domain-3 (Tim-3) in HBV infection. Tim-3 expression on both adaptive and innate immune cells is elevated in HBV infection. Increasing Tim-3 expression inhibits, and blocking Tim-3 expression rescues, the anti-viral immune response, indicating that Tim-3 is a potential target for controlling HBV infection. Finally, we describe remaining unsolved problems in this field and analyze the potential of Tim-3 as a novel drug target in the treatment of HBV-related liver diseases.
Publish Date 2016-01-31 11:48
Citation Liu Y, Gao LF, Liang XH, Ma CH. role of Tim-3 in hepatitis B virus infection: An overview. World J Gastroenterol 2016; 22(7): 2294-2303
Url http://www.wjgnet.com/1007-9327/full/v22/i7/2294.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i7.2294
Full Article (PDF) WJG-22-2294.pdf
Full Article (Word) WJG-22-2294.doc
Manuscript File 21750-Review.docx
Answering Reviewers 21750-Answering reviewers.pdf
Audio Core Tip 21750-Audio core tip.wma
Conflict-of-Interest Disclosure Form 21750-Conflict-of-interest statement.pdf
Copyright License Agreement 21750-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 21750-Language certificate.pdf
Peer-review Report 21750-Peer-review(s).pdf
Scientific Misconduct Check 21750-Scientific misconduct check.pdf
Scientific Editor Work List 21750-Scientific editor work list.pdf