Publication Name	World Journal of Gastroenterology
Manuscript ID	21750
Country	China

Received	2015-08-02 12:36
Peer-Review Started	2015-08-03 09:14
To Make the First Decision	2015-09-09 17:33
Return for Revision	2015-09-15 18:56
Revised	2015-10-08 23:43
Second Decision	2015-12-08 13:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-21 13:58
Articles in Press	2015-12-21 13:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-23 09:19
Publish the Manuscript Online	2016-01-31 11:48

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Review
Article Title	role of Tim-3 in hepatitis B virus infection: An overview
Manuscript Source	Invited Manuscript
All Author List	Yuan Liu, Li-fen Gao, Xiao-hong Liang and Chun-hong Ma
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Fund for Outstanding Youth Fund 81425012 National Natural Science Foundation of China 81100203 National Natural Science Foundation of China 81371831 National Natural Science Foundation of China 91129704 Research Fund for the Doctoral Program of Higher Education of China 20110131110034
Corresponding Author	Chun-hong Ma, PhD, Professor of Immunology, Key Laboratory for Experimental, Teratology of Ministry of Education, Shandong Provincial Key Laboratory of Infection and Immunology, Shandong University School of Medicine, 44 Wenhua Xi Road, Jinan 250012, Shandong province, China. machunhong@sdu.edu.cn
Key Words	Tim-3; Hepatitis B virus; Inflammation; Immunity; Liver disease
Core Tip	Here, we discuss the current knowledge of the interaction between hepatitis B virus (HBV) and host immunity, addressing the important role of T cell immunoglobulin domain and mucin domain-3 (Tim-3) in HBV infection. Tim-3 expression on both adaptive and innate immune cells is elevated in HBV infection. Increasing Tim-3 expression inhibits, and blocking Tim-3 expression rescues, the anti-viral immune response, indicating that Tim-3 is a potential target for controlling HBV infection. Finally, we describe remaining unsolved problems in this field and analyze the potential of Tim-3 as a novel drug target in the treatment of HBV-related liver diseases.
Publish Date	2016-01-31 11:48
Citation	Liu Y, Gao LF, Liang XH, Ma CH. role of Tim-3 in hepatitis B virus infection: An overview. World J Gastroenterol 2016; 22(7): 2294-2303
URL	http://www.wjgnet.com/1007-9327/full/v22/i7/2294.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i7.2294

Full Article (PDF)	WJG-22-2294.pdf
Full Article (Word)	WJG-22-2294.doc
Manuscript File	21750-Review.docx
Answering Reviewers	21750-Answering reviewers.pdf
Audio Core Tip	21750-Audio core tip.wma
Conflict-of-Interest Disclosure Form	21750-Conflict-of-interest statement.pdf
Copyright License Agreement	21750-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21750-Language certificate.pdf
Peer-review Report	21750-Peer-review(s).pdf
Scientific Misconduct Check	21750-Scientific misconduct check.pdf
Scientific Editor Work List	21750-Scientific editor work list.pdf