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1/29/2016 11:06:00 AM | Browse: 301 | Download: 397
Publication Name World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID 21751
Country of Manuscript Source United States
Received
2015-08-08 12:58
Peer-Review Started
2015-08-11 10:20
To Make the First Decision
2015-09-16 13:56
Return for Revision
2015-09-18 18:00
Revised
2015-10-13 05:36
Second Decision
2015-11-30 09:42
Accepted by Journal Editor-in-Chief
2015-11-30 09:54
Accepted by Company Editor-in-Chief
2015-12-11 16:39
Articles in Press
2015-12-11 16:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-01-20 14:22
Publish the Manuscript Online
2016-01-29 11:06
ISSN 2150-5349 (online)
Open Access Open-Access: This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Specialty Gastroenterology and Hepatology
Manuscript type Review
Article Title Recent discoveries and emerging therapeutics in eosinophilic esophagitis
Manuscript Source Invited Manuscript
All Author List Aakash Goyal and Edaire Cheng
Funding Agency and Grant Number
Funding Agency Grant Number
National Institutes of Health K08-DK099383 (to Cheng E)
NASPGHAN Foundation/AstraZeneca Award to Cheng E
AGA Research Scholar Award to Cheng E
Correspondence To Edaire Cheng, MD, Assistant Professor, Department of Pediatrics and Internal Medicine, Division of Gastroenterology, Children’s Health Children’s Medical Center and University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063, United States. edaire.cheng@utsouthwestern.edu
Keywords Eosinophilic esophagitis; Interleukin-5; Proton pump inhibitors; Proton pump inhibitor-responsive esophageal eosinophilia; Gastroesophageal reflux disease; Eotaxin-3
Core Tip In this review, we will discuss recent challenges and discoveries in eosinophilic esophagitis (EoE). While current treatment options are limited, mainly dietary therapy and steroids, we will highlight emerging therapeutics targeting pathogenic mechanisms of the disease. Although EoE is an allergy-mediated disease, the overlapping features of EoE and gastroesophageal reflux disease (GERD) present a diagnostic quandary in distinguishing the two disorders. EoE and GERD are not mutually exclusive and might share a complex relationship. We will review how proton pump inhibitor (PPI)s might exert therapeutic effects in EoE, and why a PPI response does not provide clear diagnostic distinction between EoE and GERD.
Publish Date 2016-01-29 11:06
Citation Goyal A, Cheng E. Recent discoveries and emerging therapeutics in eosinophilic esophagitis. World J Gastrointest Pharmacol Ther 2016; 7(1): 21-32
Url http://www.wjgnet.com/2150-5349/full/v7/i1/21.htm
DOI http://dx.doi.org/10.4292/wjgpt.v7.i1.21
Full Article (PDF) WJGPT-7-21.pdf
Full Article (Word) WJGPT-7-21.doc
Manuscript File 21751-Review.docx
Answering Reviewers 21751-Answering reviewers.pdf
Audio Core Tip 21751-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 21751-Conflict-of-interest statement.pdf
Copyright License Agreement 21751-Copyright assignment.pdf
Peer-review Report 21751-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 21751-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 21751-Scientific misconduct check.pdf
Scientific Editor Work List 21751-Scientific editor work list.pdf