Publication Name	World Journal of Gastrointestinal Pharmacology and Therapeutics
Manuscript ID	2177
Country	Italy

Received	2013-02-03 13:25
Peer-Review Started	2013-02-04 20:18
To Make the First Decision	2013-03-11 15:13
Return for Revision	2013-03-19 21:43
Revised	2013-03-29 17:15
Second Decision	2013-06-06 09:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2013-06-06 12:44
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-27 18:29
Publish the Manuscript Online	2013-08-01 15:35

ISSN	2150-5349 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Inflammatory bowel disease: An archetype disorder of outer environment sensor systems
Manuscript Source	Invited Manuscript
All Author List	Giovanni C Actis and Floriano Rosina
Funding Agency and Grant Number
Corresponding Author	Giovanni C Actis, MD, Division of Gastro-Hepatology, Ospedale Gradenigo, Corso Regina 10, 10153 Torino, Italy. actis_g@libero.it
Key Words	Inflammatory bowel disease; Psoriasis; Chronic pulmonary disease; Innate immunity; Nucleotide oligomerization domains
Core Tip	With its extended mucosal surface in contact with the environment, an overly reactive lymphoid tissue underneath, and an extraordinarily abundant metagenomic flora, the gut is in the position to play a central role in the pathogenesis of both its core disorders (inflammatory bowel disease) and remote autoinflammatory or immunopathic diseases. The IBDs have been listed as a “barrier organ dysfunction”. We hereby focus on psoriasis, a barrier organ dysfunction which is often co-morbid with IBD, sharing with it microbial receptor genetic polymorphisms, and response to therapy. This comprehensive mindset shall boost science and drive our medical choices for immunoinflammatory pathology.
Publish Date	2013-08-01 15:35
Citation	Actis GC, Rosina F. Inflammatory bowel disease: An archetype disorder of outer environment sensor systems. World J Gastrointest Pharmacol Ther 2013; 4(3): 41-46
URL	http://www.wjgnet.com/2150-5349/full/v4/i3/41.htm
DOI	http://dx.doi.org/10.4292/wjgpt.v4.i3.41

Full Article (PDF)	WJGPT-4-41.pdf
Manuscript File	2177-Review.doc
Answering Reviewers	2177-Answering reviewers.pdf
Biostatistics Review Certificate	biostatreport.doc
Copyright License Agreement	2177-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	APPROVAL CERTIFICATE.doc
Peer-review Report	2177-Peer review(s).pdf
Scientific Editor Work List	2177-Scientific editor work list.doc