Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	21796
Country	Portugal

Received	2015-07-29 09:31
Peer-Review Started	2015-07-31 11:08
To Make the First Decision	2015-10-27 11:01
Return for Revision	2015-11-06 16:23
Revised	2015-11-20 02:56
Second Decision	2016-01-25 14:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-02-16 09:05
Articles in Press	2016-02-16 09:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-09 14:53
Publish the Manuscript Online	2016-04-20 11:37

ISSN	1948-9366 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	NOD2 mutations and colorectal cancer - Where do we stand?
Manuscript Source	Invited Manuscript
All Author List	Diogo Branquinho, Paulo Freire and Carlos Sofia
Funding Agency and Grant Number
Corresponding Author	Diogo Branquinho, MD, Serviço de Gastroenterologia, Centro Hospitalar e Universitário de Coimbra, Praceta Professor Mota Pinto, 3000-075 Coimbra, Portugal. diogofbranquinho@yahoo.com
Key Words	Colorectal cancer; Fecal microbiota; Cancer susceptibility; Intestinal inflammation; Nucleotide-binding and oligomerization-domain containing 2 mutations
Core Tip	Recently, data from animal models showed that nucleotide-binding and oligomerization-domain containing 2 (NOD2) deficiency leads to dysbiosis and to an increased risk of colitis and colitis-associated colorectal cancer (CRC). Furthermore, it is now known that this receptor has a much more expanded role than previously thought. Concerning population-based studies, and despite initial inconsistencies, recent data points to an important role for NOD2 mutations in CRC susceptibility. Identifying carriers of such polymorphisms may allow them to be included in stricter CRC surveillance programs. A link between NOD2 mutation carriage and response to different chemotherapy regimens is also a promising field of research.
Publish Date	2016-04-20 11:37
Citation	Branquinho D, Freire P, Sofia C. NOD2 mutations and colorectal cancer - Where do we stand? World J Gastrointest Surg 2016; 8(4): 284-293
URL	http://www.wjgnet.com/1948-9366/full/v8/i4/284.htm
DOI	http://dx.doi.org/10.4240/wjgs.v8.i4.284

Full Article (PDF)	WJGS-8-284.pdf
Full Article (Word)	WJGS-8-284.doc
Manuscript File	21796-Review.docx
Answering Reviewers	21796-Answering reviewers.pdf
Audio Core Tip	21796-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21796-Conflict-of-interest statement.pdf
Copyright License Agreement	21796-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21796-Language certificate.pdf
Peer-review Report	21796-Peer-review(s).pdf
Scientific Misconduct Check	21796-Scientific misconduct check.pdf
Scientific Editor Work List	21796-Scientific editor work list.pdf