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Articles Published Processes
1/6/2016 4:13:00 PM | Browse: 1210 | Download: 1339
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Received |
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2015-07-30 08:53 |
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Peer-Review Started |
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2015-07-30 17:09 |
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To Make the First Decision |
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2015-09-29 12:49 |
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Return for Revision |
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2015-10-09 21:05 |
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Revised |
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2015-10-26 19:21 |
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Second Decision |
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2015-12-01 10:41 |
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Accepted by Journal Editor-in-Chief |
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2015-12-01 15:59 |
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Accepted by Executive Editor-in-Chief |
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2015-12-14 16:01 |
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Articles in Press |
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2015-12-14 16:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2015-12-25 09:49 |
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Publish the Manuscript Online |
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2016-01-06 16:13 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Topic Highlights |
| Article Title |
Viro-immune therapy: A new strategy for treatment of pancreatic cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Andrea Marie Ibrahim and Yao-He Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| The United Kingdom Charity Pancreatic Cancer Research Fund, Pancreatic Cancer Research United Kingdom |
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| Ministry of Sciences and Technology of China |
2013DFG32080 |
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| Corresponding Author |
Yao-He Wang, MD, PhD, Professor of Cancer Cell and Gene Therapy, Centre for Molecular Oncology, Barts Cancer Institute, Queen Mary University of London, EC1M6BQ London, United Kingdom. yaohe.wang@qmul.ac.uk |
| Key Words |
Anti-cytotoxic T-lymphocyte-associate protein 4; Anti-programmed death receptor ligand 1; Anti-programmed death receptor 1; Immunotherapy; Oncolytic viruses; Pancreatic ductal adenocarcinoma; Pancreatic cancer; Immune checkpoint blockade inhibitors; Cancer vaccine |
| Core Tip |
The poor prognosis of pancreatic cancer appeals for a novel strategy to treat this disease. Immunotherapies such as whole cell vaccines are currently being investigated in patients with pancreatic cancer. The recent breakthrough in cancer immunotherapy with immune checkpoint inhibitors has allowed us to reverse T cell anergy and enhance antitumour immunity. Tumour-targeted Oncolytic viruses in combination with checkpoint inhibitors function synergistically to increase the tumour antigen load, relieve immune suppression in the tumour bed while enhancing the activation of the adaptive immune system. Viro-immune-checkpoint therapy should thus be considered as a novel strategy to treat pancreatic cancer. |
| Publish Date |
2016-01-06 16:13 |
| Citation |
Ibrahim AM, Wang YH. Viro-immune therapy: A new strategy for treatment of pancreatic cancer. World J Gastroenterol 2016; 22(2): 748-763 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i2/748.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i2.748 |
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