Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	21801
Country	Italy

Received	2015-07-29 09:20
Peer-Review Started	2015-07-31 14:45
To Make the First Decision	2015-09-28 13:33
Return for Revision	2015-09-29 18:54
Revised	2015-10-07 18:23
Second Decision	2015-11-30 09:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-11 16:41
Articles in Press	2015-12-11 16:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-29 16:04
Publish the Manuscript Online	2016-02-02 18:35

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Evidence-Based Medicine
Article Title	Evaluation of antibody-dependent cell-mediated cytotoxicity activity and cetuximab response in KRAS wild-type metastatic colorectal cancer patients
Manuscript Source	Invited Manuscript
All Author List	Cristiana Lo Nigro, Vincenzo Ricci, Daniela Vivenza, Martino Monteverde, Giuliana Strola, Francesco Lucio, Federica Tonissi, Emanuela Miraglio, Cristina Granetto, Mirella Fortunato and Marco Carlo Merlano
Funding Agency and Grant Number
Corresponding Author	Cristiana Lo Nigro, PhD, Laboratory of Cancer Genetics and Translational Oncology, Oncology Department, S. Croce and Carle Teaching Hospital, Via Carle 25, 12100 Cuneo, Italy. lonigro.c@ospedale.cuneo.it
Key Words	Metastatic colorectal cancer; Single nucleotide polymorphism in Fc-γ receptors; Cetuximab; RAS family; Antibody-dependent cell-mediated cytotoxicity; Invariant natural killer T cells
Core Tip	A high number of invariant natural killer T (iNKT) cells and a high antibody-dependent cell-mediated cytotoxicity (ADCC) activity, evaluated before therapy, do correlate significantly with a longer overall survival in metastatic colorectal cancer patients treated with irinotecan-based chemotherapy and cetuximab in Ⅱ and Ⅲ lines. Chemotherapy impacted both iNKT cells and ADCC activity. The prognostic value of ADCC above the median basal level, get lost when we analysed those parameters after 2 and 4 mo of treatment. Correlation of overall survival and progression-free survival with interesting single nucleotide polymorphisms reported as involved in ADCC ability, either in the FCGR2A, FCGR3A or in the 3’ untranslated regions of KRAS gene, revealed not to be significant.
Publish Date	2016-02-02 18:35
Citation	Lo Nigro C, Ricci V, Vivenza D, Monteverde M, Strola G, Lucio F, Tonissi F, Miraglio E, Granetto C, Fortunato M, Merlano MC. Evaluation of antibody-dependent cell-mediated cytotoxicity activity and cetuximab response in KRAS wild-type metastatic colorectal cancer patients. World J Gastrointest Oncol 2016; 8(2): 222-230
URL	http://www.wjgnet.com/1948-5204/full/v8/i2/222.htm
DOI	http://dx.doi.org/10.4251/wjgo.v8.i2.222

Full Article (PDF)	WJGO-8-222.pdf
Full Article (Word)	WJGO-8-222.doc
Manuscript File	21801-Review.doc
Answering Reviewers	21801-Answering reviewers.pdf
Audio Core Tip	21801-Audio core tip.m4a
Conflict-of-Interest Disclosure Form	21801-Conflict-of-interest statement.pdf
Copyright License Agreement	21801-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150728232225.pdf
Peer-review Report	21801-Peer-review(s).pdf
Scientific Misconduct Check	21801-Scientific misconduct check.pdf
Scientific Editor Work List	21801-Scientific editor work list.pdf