Publication Name	World Journal of Transplantation
Manuscript ID	21811
Country	Germany

Received	2015-08-14 16:40
Peer-Review Started	2015-08-15 08:02
To Make the First Decision	2015-09-28 11:30
Return for Revision	2015-10-06 09:55
Revised	2015-11-02 22:40
Second Decision	2015-12-24 17:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-01-07 16:25
Articles in Press	2016-01-07 16:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-20 21:55
Publish the Manuscript Online	2016-03-18 14:28

ISSN	2220-3230 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Transplantation
Manuscript Type	Review
Article Title	Proteomics for rejection diagnosis in renal transplant patients: Where are we now?
Manuscript Source	Invited Manuscript
All Author List	Wilfried Gwinner, Jochen Metzger, Holger Husi and David Marx
Funding Agency and Grant Number	Funding Agency Grant Number Deutsche Forschungsgemeinschaft GW 4/6-1
Corresponding Author	Wilfried Gwinner, MD, Department of Nephrology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. gwinner.wilfried@mh-hannover.de
Key Words	Kidney transplantation; Acute rejection; Chronic rejection; T cell-mediated rejection; Antibody-mediated rejection; Long-term outcome; Graft failure; Biopsy; Non-invasive markers; Proteome; Proteomics; Mass spectrometry; Diagnostic marker; Study design; Diagnostic trial
Core Tip	Timely detection and treatment of acute and chronic rejection is important to maintain the allograft function in renal transplant patients. Allograft biopsies are unsuitable for continuous monitoring for rejection. This review summarizes the past experience with proteomic approaches to diagnose rejection non-invasively. Potential limitations and open questions in establishing proteomic markers for rejection are discussed, including ongoing trials and future challenges to this topic.
Publish Date	2016-03-18 14:28
Citation	Gwinner W, Metzger J, Husi H, Marx D. Proteomics for rejection diagnosis in renal transplant patients: Where are we now? World J Transplant 2016; 6(1): 28-41
URL	http://www.wjgnet.com/2220-3230/full/v6/i1/28.htm
DOI	http://dx.doi.org/10.5500/wjt.v6.i1.28

Full Article (PDF)	WJT-6-28.pdf
Full Article (Word)	WJT-6-28.doc
Manuscript File	21811-Review.doc
Answering Reviewers	21811-Answering reviewers.pdf
Audio Core Tip	21811-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21811-Conflict-of-interest statement.pdf
Copyright License Agreement	21811-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20150814143810.pdf
Supplementary Material	Supplementary_Material_20150814144153.pdf
Peer-review Report	21811-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21811-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21811-Scientific misconduct check.pdf
Scientific Editor Work List	21811-Scientific editor work list.pdf