Publication Name	World Journal of Gastroenterology
Manuscript ID	21841
Country	Japan

Received	2015-07-29 14:00
Peer-Review Started	2015-07-30 14:00
To Make the First Decision	2015-09-09 17:33
Return for Revision	2015-09-15 19:11
Revised	2015-10-04 07:26
Second Decision	2015-10-23 16:32
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-11-09 17:16
Articles in Press	2015-11-09 17:17
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-19 19:04
Publish the Manuscript Online	2016-01-15 14:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Recent advances in photodynamic diagnosis of gastric cancer using 5-aminolevulinic acid
Manuscript Source	Invited Manuscript
All Author List	Noriaki Koizumi, Yoshinori Harada, Takeo Minamikawa, Hideo Tanaka, Eigo Otsuji and Tetsuro Takamatsu
Funding Agency and Grant Number
Corresponding Author	Tetsuro Takamatsu, MD, PhD, Depart­ment of Medical Photonics, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, 465 Kajii-cho, Kawaramachi-Hirokoji, Kamigyo-ku, Kyoto 6028566, Japan. ttakam@koto.kpu-m.ac.jp
Key Words	Gastric cancer; Photodynamic diagnosis; 5-aminolevulinic acid; Protoporphyrin IX; Lymph node metastasis; Personalized medicine; Peritoneal dissemination
Core Tip	To perform personalized treatment for gastric cancer, rapid intraoperative detection of malignant lesions is desirable. Photodynamic diagnosis based on 5-aminolevulinic acid-induced protoporphyrin Ⅸ may help in this regard. This method enables intraoperative real-time fluorescence detection of peritoneal dis-semination in gastric cancer patients, exhibiting higher sensitivity than white light observation without histopathological examination. The method also enables detection of metastatic foci within excised lymph nodes, exhibiting a diagnostic accuracy com-parable to a current molecular diagnostics technique. This method has the potential to become a useful diagnostic tool for gastric cancer treatment.
Publish Date	2016-01-15 14:54
Citation	Koizumi N, Harada Y, Minamikawa T, Tanaka H, Otsuji E, Takamatsu T. Recent advances in photodynamic diagnosis of gastric cancer using 5-aminolevulinic acid. World J Gastroenterol 2016; 22(3): 1289-1296
URL	http://www.wjgnet.com/1007-9327/full/v22/i3/1289.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i3.1289

Full Article (PDF)	WJG-22-1289.pdf
Full Article (Word)	WJG-22-1289.doc
Manuscript File	21841-Review.docx
Answering Reviewers	21841-Answering reviewers.pdf
Audio Core Tip	21841-Audio core tip.wav
Conflict-of-Interest Disclosure Form	21841-Conflict-of-interest statement.pdf
Copyright License Agreement	21841-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21841-Language certificate.pdf
Peer-review Report	21841-Peer-review(s).pdf
Scientific Misconduct Check	21841-Scientific misconduct check.pdf
Scientific Editor Work List	21841-Scientific editor work list.pdf