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Articles Published Processes
3/18/2016 2:28:00 PM | Browse: 886 | Download: 1223
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Received |
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2015-08-04 09:05 |
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Peer-Review Started |
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2015-08-05 16:08 |
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To Make the First Decision |
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2015-09-16 13:57 |
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Return for Revision |
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2015-09-21 18:25 |
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Revised |
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2015-10-03 23:18 |
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Second Decision |
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2015-11-23 09:18 |
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Accepted by Journal Editor-in-Chief |
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2015-11-24 23:19 |
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Accepted by Executive Editor-in-Chief |
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2015-12-04 16:44 |
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Articles in Press |
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2015-12-04 16:44 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-02-29 19:17 |
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Publish the Manuscript Online |
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2016-03-18 14:28 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Ophthalmology |
| Manuscript Type |
Review |
| Article Title |
High-risk corneal allografts: A therapeutic challenge
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Tian Yu, Vijayalakshmi Rajendran, May Griffith, John V Forrester and Lucia Kuffová |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Saving Sight in Grampian, Development Trust of University of Aberdeen, United Kingdom |
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| Action Medical Research United Kingdom |
SP4328 |
| Linköping University, Sweden |
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| Corresponding Author |
Lucia Kuffová, MD, PhD, Section of Immunity, Infection and Inflammation, Division of Applied Medicine, School of Medicine and Dentistry, Institute of Medical Sciences, University of Aberdeen, Scotland AB25 2ZD,
United Kingdom. l.kuffova@abdn.ac.uk
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| Key Words |
“High-risk” grafts; Graft rejection; Systemic immunosuppression; Cell-based immunomodulation; Keratoprosthesis; Collagen-based hydrogels |
| Core Tip |
Corneal grafts enjoy a high acceptance rate when performed in “low-risk” host graft beds. This is associated with a relatively weak alloimmune response. However, in “high-risk” hosts where the immunologically quiescent homeostatic environment of the cornea is compromised prior to graft procedure, heightened immune responses significantly increase the risk of graft rejection. Clinical approaches such as tissue matching and long-term immunosuppression could be beneficial in preventing graft rejection especially in “high-risk” settings. In addition, promotion of transplant tolerance by cell-based therapies and use of corneal “substitutes” such as collagen-based hydrogels are promising alternatives for “high-risk” recipients.
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| Publish Date |
2016-03-18 14:28 |
| Citation |
Yu T, Rajendran V, Griffith M, Forrester JV, Kuffová L. High-risk corneal allografts: A therapeutic challenge. World J Transplant 2016; 6(1): 10-27 |
| URL |
http://www.wjgnet.com/2220-3230/full/v6/i1/10.htm |
| DOI |
http://dx.doi.org/10.5500/wjt.v6.i1.10 |
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