Publication Name	World Journal of Gastroenterology
Manuscript ID	21876
Country	China

Received	2015-07-31 17:24
Peer-Review Started	2015-08-01 16:43
To Make the First Decision	2015-08-26 13:54
Return for Revision	2015-08-28 17:03
Revised	2015-08-31 11:00
Second Decision	2015-10-12 16:39
Accepted by Journal Editor-in-Chief	2015-10-14 13:01
Accepted by Company Editor-in-Chief	2015-10-20 09:45
Articles in Press	2015-10-20 09:45
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-11-06 08:48
Typeset the Manuscript	2015-11-26 14:39
Publish the Manuscript Online	2015-12-15 12:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Surgery
Manuscript Type	Basic Study
Article Title	Evaluation of epithelial-mesenchymal transitioned circulating tumor cells in patients with resectable gastric cancer: Relevance to therapy response
Manuscript Source	Unsolicited Manuscript
All Author List	Ting-Ting Li, Hao Liu, Feng-Ping Li, Yan-Feng Hu, Ting-Yu Mou, Tian Lin, Jiang Yu, Lei Zheng and Guo-Xin Li
Funding Agency and Grant Number	Funding Agency Grant Number Science and Technology Major Program of Guangzhou 201300000087 Public Welfare in Health Industry of National Health and Family Planning Commission of China 201402015 Public Welfare in Health Industry of National Health and Family Planning Commission of China 201502039 Key Clinical Specialty Discipline Construction Program National Key Technology R&D Program 2013BAI05B05
Corresponding Author	Guo-Xin Li, MD, PhD, FRCS, Department of General Surgery, Nanfang Hospital, Southern Medical University, 1838 North Guangzhou Avenue, Guangzhou 510515, Guangdong Province, China. gzliguoxin@163.com
Key Words	gastric cancer; Epithelial-to-mesenchymal transition; circulating tumor cells; Chemotherapy; Therapy response
Core Tip	Epithelial-to-mesenchymal transition has been thought to play a critical role in tumor meta-static progression in preclinical models, however, characterizing the epithelial vs mesenchymal phe-notypes of circulating tumor cells has been challenging. In this study, we aimed to evaluate epithelial-to-mesenchymal transition phenomenon in circulating gastric tumor cells by a combination of physical and biological methods. Our findings have provided evidence of the phenomenon both in rare cells within primary tumors and more abundantly in circulating tumor cells. Furthermore, we demonstrated that the evaluation of the mesenchymal circulating tumor cells in peripheral blood can be used to monitor therapy response in gastric cancer patients.
Publish Date	2015-12-15 12:22
Citation	Li TT, Liu H, Li FP, Hu YF, Mou TY, Lin T, Yu J, Zheng L, Li GX. Evaluation of epithelial-mesenchymal transitioned circulating tumor cells in patients with resectable gastric cancer: Relevance to therapy response. World J Gastroenterol 2015; 21(47): 13259-13267
URL	http://www.wjgnet.com/1007-9327/full/v21/i47/13259.htm
DOI	http://dx.doi.org/10.3748/wjg.v21.i47.13259

Full Article (PDF)	WJG-21-13259.pdf
Full Article (Word)	WJG-21-13259.doc
Manuscript File	21876-Review.docx
Answering Reviewers	21876-Answering reviewers.pdf
Audio Core Tip	21876-Audio core tip.wma
Biostatistics Review Certificate	21876-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	21876-Conflict-of-interest statement.pdf
Copyright License Agreement	21876-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	21876-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	21876-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	21876-Language certificate.pdf
Peer-review Report	21876-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21876-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21876-Scientific misconduct check.pdf
Scientific Editor Work List	21876-Scientific editor work list.pdf