Publication Name	World Journal of Gastroenterology
Manuscript ID	21909
Country	China

Received	2015-08-07 09:10
Peer-Review Started	2015-08-10 09:05
To Make the First Decision	2015-11-13 09:32
Return for Revision	2015-11-13 15:51
Revised	2015-11-19 20:46
Second Decision	2015-11-26 16:16
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-12-08 16:34
Articles in Press	2015-12-08 16:34
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-12-20 22:13
Typeset the Manuscript	2016-03-01 13:42
Publish the Manuscript Online	2016-03-23 16:22

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites
Manuscript Source	Unsolicited Manuscript
All Author List	Chao Chen, Ren-Pin Chen, Hai-Hua Lin, Wen-You Zhang, Xie-Lin Huang and Zhi-Ming Huang
Funding Agency and Grant Number	Funding Agency Grant Number Crosswise Project KJHX1310
Corresponding Author	Dr. Zhi-Ming Huang, Professor, Department of Gastroenterology, the First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Ouhai District, Wenzhou 325000, Zhejiang Province, China. wyyyhzm@126.com
Key Words	Tolvaptan; Aquaporin-2; Cirrhosis; Ascites
Core Tip	Aquaporin (AQP)-2 is mainly expressed in the kidneys, although it has been detected in the distal colon. We confirmed its expression in the distal colon and its upregulation in cirrhotic rats with ascites. Tolvaptan is a highly potent and selective AQP-2 antagonist and is used to treat cirrhotic ascites and hyponatremia. It blocked AQP-2 expression in the distal colon after oral administration, and temporarily increased fecal water content. Fecal water content returned to baseline quickly. The results suggest that tolvaptan inhibited AQP-2 expression in the distal colon and may induce diarrhea to clear water.
Publish Date	2016-03-23 16:22
Citation	Chen C, Chen RP, Lin HH, Zhang WY, Huang XL, Huang ZM. Tolvaptan regulates aquaporin-2 and fecal water in cirrhotic rats with ascites. World J Gastroenterol 2016; 22(12): 3363-3371
URL	http://www.wjgnet.com/1007-9327/full/v22/i12/3363.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i12.3363

Full Article (PDF)	WJG-22-3363.pdf
Full Article (Word)	WJG-22-3363.doc
Manuscript File	21909-Review.docx
Answering Reviewers	21909-Answering reviewers.pdf
Audio Core Tip	21909-Audio core tip.mp3
Biostatistics Review Certificate	21909-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	21909-Conflict-of-interest statement.pdf
Copyright License Agreement	21909-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document	21909-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document	21909-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	21909-Language certificate.pdf
Peer-review Report	21909-Peer-review(s).pdf
Scientific Misconduct Check	21909-Scientific misconduct check.pdf
Scientific Editor Work List	21909-Scientific editor work list.pdf