Publication Name	World Journal of Nephrology
Manuscript ID	21958
Country	Japan

Received	2015-08-10 13:51
Peer-Review Started	2015-08-11 17:55
To Make the First Decision	2015-09-16 13:58
Return for Revision	2015-09-21 19:11
Revised	2015-09-27 09:42
Second Decision	2015-11-09 10:53
Accepted by Journal Editor-in-Chief	2015-11-09 16:36
Accepted by Executive Editor-in-Chief	2015-11-25 16:34
Articles in Press	2015-11-25 16:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-29 18:05
Publish the Manuscript Online	2016-01-06 20:46

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Research & Experimental Medicine
Manuscript Type	Review
Article Title	Adult stem cells as a tool for kidney regeneration
Manuscript Source	Invited Manuscript
All Author List	Etsu Suzuki, Daishi Fujita, Masao Takahashi, Shigeyoshi Oba and Hiroaki Nishimatsu
Funding Agency and Grant Number
Corresponding Author	Etsu Suzuki, MD, PhD, Institute of Medical Science, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8512, Japan. esuzuki-tky@umin.ac.jp
Key Words	Adult stem cells; Direct reprogramming; Extracellular vesicles; Mesenchymal stem cells; Paracrine factors; Indirect reprogramming
Core Tip	Although intensive studies have been performed to isolate kidney stem/progenitor cells from the mammalian adult kidney, whether stem/progenitor cells actually exist in the adult kidney is still debated. Mesenchymal stem cells seem to exert beneficial effects via paracrine effects rather than by direct differentiation into renal parenchymal cells. In this review, we also introduce potential roles of extracellular vesicles released from stem cells and direct/indirect reprogramming of adult somatic cells by which kidney stem/progenitor cells will be formed in the future.
Publish Date	2016-01-06 20:46
Citation	Suzuki E, Fujita D, Takahashi M, Oba S, Nishimatsu H. Adult stem cells as a tool for kidney regeneration. World J Nephrol 2016; 5(1): 43-52
URL	http://www.wjgnet.com/2220-6124/full/v5/i1/43.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i1.43

Full Article (PDF)	WJN-5-43.pdf
Full Article (Word)	WJN-5-43.doc
Manuscript File	21958-Review.docx
Answering Reviewers	21958-Answering reviewers.pdf
Audio Core Tip	21958-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21958-Conflict-of-interest statement.pdf
Copyright License Agreement	21958-Copyright assignment.pdf
Peer-review Report	21958-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21958-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21958-Scientific misconduct check.pdf
Scientific Editor Work List	21958-Scientific editor work list.pdf