Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	21986
Country	United Kingdom

Received	2015-08-08 13:09
Peer-Review Started	2015-08-11 17:16
To Make the First Decision	2015-09-16 13:58
Return for Revision	2015-09-22 10:02
Revised	2015-10-24 00:11
Second Decision	2015-12-17 18:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-01-04 17:01
Articles in Press	2016-01-04 17:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-14 17:49
Publish the Manuscript Online	2016-03-20 21:10

ISSN	1948-9366 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Pathology
Manuscript Type	Review
Article Title	Assessment of lymph node involvement in colorectal cancer
Manuscript Source	Invited Manuscript
All Author List	Mark LH Ong and John B Schofield
Funding Agency and Grant Number
Corresponding Author	John Schofield, MBBS, Professor, Consultant Histopathologist, Department of Histopathology, Maidstone Hospital, Hermitage Lane, Maidstone, Kent ME16 9QQ, United Kingdom. john.schofield@nhs.net
Key Words	Colorectal cancer; Lymphatic metastases; Lymph node metastasis; Neoplasm staging; Tumor node metastasis classification; Sentinel lymph node biopsy; Lymph node excision; Histopathological assessment; Surgery
Core Tip	The number of lymph nodes in surgical rese-ction specimens is influenced by numerous factors. Good practice by surgeons and pathologists is essential to maximize lymph node yields, but there are non-modifiable factors related to patient and tumour. Extended lymphadenectomy, extra-mesenteric lymph node dissection, high arterial ligation and complete mesocolic excision, all increase lymph node yields, but a definite benefit in prognosis is not proven and the optimal extent of surgical resection remains contentious. Conversely, further development in sentinel lymph node biopsy techniques could allow selective lymphadenectomy, whilst providing appropriate information to guide adjuvant therapy.
Publish Date	2016-03-20 21:10
Citation	Ong MLH, Schofield JB. Assessment of lymph node involvement in colorectal cancer. World J Gastrointest Surg 2016; 8(3): 179-192
URL	http://www.wjgnet.com/1948-9366/full/v8/i3/179.htm
DOI	http://dx.doi.org/10.4240/wjgs.v8.i3.179

Full Article (PDF)	WJGS-8-179.pdf
Full Article (Word)	WJGS-8-179.doc
Manuscript File	21986-Review.doc
Answering Reviewers	21986-Answering reviewers.pdf
Audio Core Tip	21986-Audio core tip.MP3
Conflict-of-Interest Disclosure Form	21986-Conflict-of-interest statement.pdf
Copyright License Agreement	21986-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21986-Language certificate.pdf
Supplementary Material	Supplementary_Material_20150804190253.png
Peer-review Report	21986-Peer-review(s).pdf
Scientific Misconduct Check	21986-Scientific misconduct check.pdf
Scientific Editor Work List	21986-Scientific editor work list.pdf