Publication Name	World Journal of Critical Care Medicine
Manuscript ID	21989
Country	France

Received	2015-08-05 09:36
Peer-Review Started	2015-08-06 09:51
To Make the First Decision	2015-09-16 13:59
Return for Revision	2015-09-22 10:06
Revised	2015-09-29 22:15
Second Decision	2015-11-23 09:19
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-04 16:47
Articles in Press	2015-12-04 16:47
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-15 08:29
Publish the Manuscript Online

ISSN	2220-3141(online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Critical Care Medicine
Manuscript Type	Review
Article Title	Use of venous-to-arterial carbon dioxide tension difference to guide resuscitation therapy in septic shock
Manuscript Source	Invited Manuscript
All Author List	Jihad Mallat, Malcolm Lemyze, Laurent Tronchon, Benoît Vallet and Didier Thevenin
Funding Agency and Grant Number
Corresponding Author	Jihad Mallat, MD, Department of Anesth¬esiology and Critical Care Medicine, Centre Hospitalier du Dr. Schaffner de Lens, 99 route de La Bassée, 62300 Lens, France. mallatjihad@gmail.com
Key Words	Venous-to-arterial carbon dioxide tension difference; Carbon dioxide production; Oxygen supply dependency; Cardiac output; tissue hypoxia; Anaerobic metabolism; Oxygen consumption; Resuscitation; Septic shock
Core Tip	Early recognition and correction of tissue hypoperfusion are cornerstones in the management of septic shock patients. The venous-to-arterial carbon dioxide tension difference, which is a marker of the adequacy of cardiac output to global metabolic demand, is a helpful additional means to detect patients who stay under-resuscitated after optimization of O2-derived parameters. In this regard, its monitoring should help the clinicians for the decision of giving therapy targeting at increasing cardiac output.
Publish Date
Citation	Mallat J, Lemyze M, Tronchon L, Vallet B, Thevenin D. Use of venous-to-arterial carbon dioxide tension difference to guide resuscitation therapy in septic shock. World J Crit Care Med 2016; 5(1): 47-56
URL	http://www.wjgnet.com/2220-3141/full/v5/i1/47.htm
DOI	http://dx.doi.org/10.5492/wjccm.v5.i1.47

Full Article (PDF)	WJCCM-5-47.pdf
Full Article (Word)	WJCCM-5-47.doc
Manuscript File	21989-Review.doc
Answering Reviewers	21989-Answering reviewers.pdf
Audio Core Tip	21989-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21989-Conflict-of-interest statement.pdf
Copyright License Agreement	21989-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	21989-Language certificate.pdf
Peer-review Report	21989-Peer-review(s).pdf
Scientific Misconduct Check	21989-Scientific misconduct check.pdf
Scientific Editor Work List	21989-Scientific editor work list.pdf