Publication Name	World Journal of Translational Medicine
Manuscript ID	21996
Country	United Kingdom

Received	2015-08-05 15:14
Peer-Review Started	2015-08-07 16:34
To Make the First Decision	2015-10-27 11:25
Return for Revision	2015-11-03 10:37
Revised
Second Decision	2015-12-17 18:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2016-01-04 17:05
Articles in Press	2016-01-04 17:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-29 14:08
Publish the Manuscript Online	2016-04-11 10:17

ISSN	2220-6132 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Potential therapeutic targets from genetic and epigenetic approaches for asthma
Manuscript Source	Invited Manuscript
All Author List	Youming Zhang
Funding Agency and Grant Number
Corresponding Author	Dr. Youming Zhang, Genomic Medicine Section, National Heart and Lung Institute, Dovehouse Street, London SW3 6LY, United Kingdom. y.zhang@imperial.ac.uk
Key Words	Asthma; Immunoglobulin E; Genome-wide association studies; Epigenetics; MicroRNA
Core Tip	Asthma is a complex disorder characterised by inflammation of airway. Allergic asthma is an immuno-globulin E (IgE) related disease. Severe asthma remains difficult to treat. Genetic and genomic approaches of asthma and IgE identified many novel loci underling the disease pathophysiology. Recent epigenetic approaches also revealed the insights of DNA methylation and chromatin modification on histones in asthma and IgE. More than 30 microRNAs have been identified to have regulation roles in asthma. Understanding the pathways of the novel genetic loci and epigenetic elements in asthma and IgE will provide new therapeutic means for clinical management of the disease in future.
Publish Date	2016-04-11 10:17
Citation	Zhang Y. Potential therapeutic targets from genetic and epigenetic approaches for asthma. World J Transl Med 2016; 5(1): 14-25
URL	http://www.wjgnet.com/2220-6132/full/v5/i1/14.htm
DOI	http://dx.doi.org/10.5528/wjtm.v5.i1.14

Full Article (PDF)	WJTM-5-14.pdf
Full Article (Word)	WJTM-5-14.doc
Manuscript File	21996-Review.docx
Answering Reviewers	21996-Answering reviewers.pdf
Audio Core Tip	21996-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21996-Conflict-of-interest statement.pdf
Copyright License Agreement	21996-Copyright assignment.pdf
Peer-review Report	21996-Peer-review(s).pdf
Scientific Misconduct Check	21996-Scientific misconduct check.pdf
Scientific Editor Work List	21996-Scientific editor work list.pdf