Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	21998
Country	Singapore

Received	2015-08-05 16:25
Peer-Review Started
To Make the First Decision
Return for Revision
Revised
Second Decision	2015-08-05 18:10
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-08-05 18:15
Articles in Press	2015-08-05 18:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-09-06 15:52
Publish the Manuscript Online	2015-09-17 15:08

ISSN	1948-5204 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Minireviews
Article Title	Hereditary diffuse gastric cancer: What the clinician should know
Manuscript Source	Invited Manuscript
All Author List	Ryan Ying Cong Tan and Joanne Ngeow
Funding Agency and Grant Number
Corresponding Author	Joanne Ngeow, MBBS, MRCP, MPH, Cancer Genetics Service, Division of Medical Oncology, National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore. joanne.ngeow.y.y@singhealth.com.sg
Key Words	Hereditary diffuse gastric cancer; CDH1; CTNNA1; MAP3K6; Gastrectomy
Core Tip	While the incidence of hereditary diffuse gastric cancer remains low, it is an important clinical entity to recognize due to its high pathogenicity and penetrance. The International Gastric Cancer Linkage Consortium has outlined CDH1 testing criteria and developed clinical utility gene cards to help clinicians manage such patients. Significant progress has been made in recent years and in future, testing of other genes is likely for CDH1-negative families. The mainstay of treatment for asymptomatic carriers of CDH1 pathogenic mutations remains prophylactic total gastrectomy. Future research should focus on better risk stratification and surveillance methods.
Publish Date	2015-09-17 15:08
Citation	Tan RYC, Ngeow J. Hereditary diffuse gastric cancer: What the clinician should know. World J Gastrointest Oncol 2015; 7(9): 153-160
URL	http://www.wjgnet.com/1948-5204/full/v7/i9/153.htm
DOI	http://dx.doi.org/10.4251/wjgo.v7.i9.153

Full Article (PDF)	WJGO-7-153.pdf
Full Article (Word)	WJGO-7-153.doc
Manuscript File	21998-Review.doc
Answering Reviewers	21998-Answering reviewers.pdf
Audio Core Tip	21998-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	21998-Conflict-of-interest statement.pdf
Copyright License Agreement	21998-Copyright assignment.pdf
Peer-review Report	21998-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	21998-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	21998-Scientific misconduct check.pdf
Scientific Editor Work List	21998-Scientific editor work list.pdf