Publication Name	World Journal of Stem Cells
Manuscript ID	22054
Country	Canada

Received	2015-08-08 12:55
Peer-Review Started	2015-08-11 10:06
To Make the First Decision	2015-09-16 13:59
Return for Revision	2015-09-22 10:56
Revised
Second Decision	2015-11-09 10:54
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-11-25 16:35
Articles in Press	2015-11-25 16:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2015-12-16 10:50
Publish the Manuscript Online	2015-12-25 08:04

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Research & Experimental Medicine
Manuscript Type	Review
Article Title	Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapy
Manuscript Source	Invited Manuscript
All Author List	Murtaza S Nagree, Lucía López-Vásquez and Jeffrey A Medin
Funding Agency and Grant Number	Funding Agency Grant Number Canadian Institutes of Health Research Grant MOP-123528(to Medin JA)
Corresponding Author	Jeffrey A Medin, PhD, University Health Network, 5R406 Max Bell Research Centre, 101 College Street, Toronto, ON M5G 1L7, Canada. jmedin@uhnresearch.ca
Key Words	Gene therapy; Hematopoietic stem cells; In vivo selection; Chemical Inducer of Dimerization; Chemo-selection; Lentivirus
Core Tip	Though hematopoietic stem cell (HSC)-directed gene therapy is becoming a viable therapy for many disorders, optimization of clinical output needs improvement. One approach to circumvent lower efficiencies of gene transfer and/or engraftment is to apply in vivo amplification strategies. Here we review various modules that have been developed and tested to mediate amplification of HSCs after gene transfer.
Publish Date	2015-12-25 08:04
Citation	Nagree MS, López-Vásquez L, Medin JA. Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapy. World J Stem Cells 2015; 7(11): 1233-1250
URL	http://www.wjgnet.com/1948-0210/full/v7/i11/1233.htm
DOI	http://dx.doi.org/10.4252/wjsc.v7.i11.1233

Full Article (PDF)	WJSC-7-1233.pdf
Full Article (Word)	WJSC-7-1233.doc
Manuscript File	22054-Review.docx
Answering Reviewers	22054-Answering reviewers.pdf
Audio Core Tip	22054-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22054-Conflict-of-interest statement.pdf
Copyright License Agreement	22054-Copyright assignment.pdf
Peer-review Report	22054-Peer-review(s).pdf
Scientific Misconduct Check	22054-Scientific misconduct check.pdf
Scientific Editor Work List	22054-Scientific editor work list.pdf