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12/25/2015 8:04:00 AM | Browse: 434 | Download: 585
Publication Name World Journal of Stem Cells
Manuscript ID 22054
Country/Territory Canada
Received
2015-08-08 12:55
Peer-Review Started
2015-08-11 10:06
To Make the First Decision
2015-09-16 13:59
Return for Revision
2015-09-22 10:56
Revised
Second Decision
2015-11-09 10:54
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-11-25 16:35
Articles in Press
2015-11-25 16:35
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2015-12-16 10:50
Publish the Manuscript Online
2015-12-25 08:04
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Research and Experimental Medicine
Manuscript Type Review
Article Title Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapy
Manuscript Source Invited Manuscript
All Author List Murtaza S Nagree, Lucía López-Vásquez and Jeffrey A Medin
Funding Agency and Grant Number
Funding Agency Grant Number
Canadian Institutes of Health Research Grant MOP-123528(to Medin JA)
Corresponding author Jeffrey A Medin, PhD, University Health Network, 5R406 Max Bell Research Centre, 101 College Street, Toronto, ON M5G 1L7, Canada. jmedin@uhnresearch.ca
Key Words Gene therapy; Hematopoietic stem cells; In vivo selection; Chemical Inducer of Dimerization; Chemo-selection; Lentivirus
Core Tip Though hematopoietic stem cell (HSC)-directed gene therapy is becoming a viable therapy for many disorders, optimization of clinical output needs improvement. One approach to circumvent lower efficiencies of gene transfer and/or engraftment is to apply in vivo amplification strategies. Here we review various modules that have been developed and tested to mediate amplification of HSCs after gene transfer.
Publish Date 2015-12-25 08:04
Citation Nagree MS, López-Vásquez L, Medin JA. Towards in vivo amplification: Overcoming hurdles in the use of hematopoietic stem cells in transplantation and gene therapy. World J Stem Cells 2015; 7(11): 1233-1250
Url http://www.wjgnet.com/1948-0210/full/v7/i11/1233.htm
DOI http://dx.doi.org/10.4252/wjsc.v7.i11.1233
Full Article (PDF) WJSC-7-1233.pdf
Full Article (Word) WJSC-7-1233.doc
Manuscript File 22054-Review.docx
Answering Reviewers 22054-Answering reviewers.pdf
Audio Core Tip 22054-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 22054-Conflict-of-interest statement.pdf
Copyright License Agreement 22054-Copyright assignment.pdf
Peer-review Report 22054-Peer-review(s).pdf
Scientific Misconduct Check 22054-Scientific misconduct check.pdf
Scientific Editor Work List 22054-Scientific editor work list.pdf