Publication Name	World Journal of Gastrointestinal Pathophysiology
Manuscript ID	22072
Country	United States

Received	2015-08-11 14:22
Peer-Review Started	2015-08-11 16:11
First Decision by Editorial Office Director
Return for Revision	2015-10-06 11:13
Revised	2015-10-18 04:49
Publication Fee Transferred
Second Decision by Editor	2015-11-12 14:04
Second Decision by Editor-in-Chief	2015-11-15 11:47
Final Decision by Editorial Office Director	2015-11-25 15:41
Articles in Press	2015-11-25 15:41
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-23 16:43
Publish the Manuscript Online	2016-01-31 16:11

ISSN	2150-5330 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Mechanisms of interleukin-22’s beneficial effects in acute pancreatitis
Manuscript Source	Invited Manuscript
All Author List	Chongmin Huan, Daniel Kim, Peiqi Ou, Antonio Alfonso and Albert Stanek
Funding Agency and Grant Number
Corresponding Author	Chongmin Huan, MD, PhD, Assistant Professor, Department of Surgery, Downstate Medical Center, State University of New York, 450 Clarkson Avenue, Brooklyn, NY 11203, United States. chongmin.huan@downstate.edu
Key Words	Interleukin-22; Acute pancreatitis; Cytokine; Inflammatory response; Acinar cell
Core Tip	Interleukin (IL)-22 has been recognized as a potential therapeutic agent for acute pancreatitis (AP) treatment due to its discovered beneficial effects in inflammatory diseases. However, according to recent publications and our results, IL-22 appears to have differential effects in AP depending on the severity of the disorder. In this review we discuss the different regulatory mechanisms of IL-22 in mild and severe AP models in order to promote development of an effective and efficient therapeutic approach.
Publish Date	2016-01-31 16:11
Citation	Huan C, Kim D, Ou P, Alfonso A, Stanek A. Mechanisms of interleukin-22’s beneficial effects in acute pancreatitis. World J Gastrointest Pathophysiol 2016; 7(1): 108-116
URL	http://www.wjgnet.com/2150-5330/full/v7/i1/108.htm
DOI	http://dx.doi.org/10.4291/wjgp.v7.i1.108

Full Article (PDF)	WJGP-7-108.pdf
Full Article (Word)	WJGP-7-108.doc
Manuscript File	22072-Review.docx
Answering Reviewers	22072-Answering reviewers.pdf
Audio Core Tip	22072-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22072-Conflict-of-interest statement.pdf
Copyright License Agreement	22072-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	Editing_Certificate_20150811131503.pdf
Peer-review Report	22072-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22072-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22072-Scientific misconduct check.pdf
Scientific Editor Work List	22072-Scientific editor work list.pdf