Publication Name	World Journal of Hepatology
Manuscript ID	22175
Country	Thailand

Received	2015-08-18 08:30
Peer-Review Started	2015-08-21 12:10
To Make the First Decision	2015-10-08 16:09
Return for Revision	2015-10-13 15:52
Revised	2015-11-23 16:27
Second Decision	2016-01-20 16:33
Accepted by Journal Editor-in-Chief	2016-01-20 19:07
Accepted by Executive Editor-in-Chief	2016-01-29 17:31
Articles in Press	2016-01-29 17:31
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-02 14:07
Publish the Manuscript Online	2016-02-22 15:38

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Bacterial infections in cirrhosis: A critical review and practical guidance
Manuscript Source	Invited Manuscript
All Author List	Chalermrat Bunchorntavakul, Naichaya Chamroonkul and Disaya Chavalitdhamrong
Funding Agency and Grant Number
Corresponding Author	Chalermrat Bunchorntavakul, MD, Assistant Professor of Medicine, Division of Gastroenterology and Hepatology, Department of Internal Medicine, Rajavithi Hospital, College of Medicine, Rangsit University, Rajavithi Road, Ratchathewi, Bangkok 10400, Thailand. dr.chalermrat@gmail.com
Key Words	Bacteria; Infection; Sepsis; Bacteremia; Liver cirrhosis; Vaccination; Spontaneous peritonitis; Immune dysfunction
Core Tip	Bacterial infection is common and accounts for major morbidity and mortality in cirrhosis. Patients with cirrhosis are immunocompromised and increased susceptibility to develop spontaneous bacterial infec-tions, hospital-acquired infections, and a variety of infections from uncommon pathogens. Once infection develops, the excessive response of pro-inflammatory cytokines on a pre-existing hemodynamic derangement in cirrhosis further predispose the development of serious complications such as shock, acute-on-chronic liver failure, renal failure, and death. The incidence of resistant bacteria has continually increased, especially in healthcare-associated settings. Preventive measures, early recognition and proper management are necessary to minimize morbidity and mortality of infections in cirrhosis.
Publish Date	2016-02-22 15:38
Citation	Bunchorntavakul C, Chamroonkul N, Chavalitdhamrong D. Bacterial infections in cirrhosis: A critical review and practical guidance. World J Hepatol 2016; 8(6): 307-321
URL	http://www.wjgnet.com/1948-5182/full/v8/i6/307.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i6.307

Full Article (PDF)	WJH-8-307.pdf
Full Article (Word)	WJH-8-307.doc
Manuscript File	22175-Review.doc
Answering Reviewers	22175-Answering reviewers.pdf
Audio Core Tip	22175-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22175-Conflict-of-interest statement.pdf
Copyright License Agreement	22175-Copyright assignment.pdf
Peer-review Report	22175-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22175-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22175-Scientific misconduct check.pdf
Scientific Editor Work List	22175-Scientific editor work list.pdf