Publication Name	World Journal of Gastroenterology
Manuscript ID	22177
Country	United States

Received	2015-08-18 08:27
Peer-Review Started	2015-08-18 14:01
To Make the First Decision	2015-09-29 17:03
Return for Revision	2015-10-05 14:12
Revised	2015-11-05 00:43
Second Decision	2015-11-25 18:30
Accepted by Journal Editor-in-Chief	2015-11-27 08:01
Accepted by Executive Editor-in-Chief	2015-12-08 17:09
Articles in Press	2015-12-08 17:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-18 17:20
Publish the Manuscript Online	2016-03-04 19:53

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Oncology
Manuscript Type	Retrospective Study
Article Title	Factors associated with increased incidence of severe toxicities following yttrium-90 resin microspheres in the treatment of hepatic malignancies
Manuscript Source	Unsolicited Manuscript
All Author List	John D Roberson II, Andrew M McDonald, Craig J Baden, Chee Paul Lin, Rojymon Jacob and Omer L Burnett III
Funding Agency and Grant Number	Funding Agency Grant Number National Center for Advancing Translational Sciences of the National Institutes of Health under award UL1TR00165
Corresponding Author	John D Roberson II, BS, Medical Student, School of Medicine, University of Alabama at Birmingham, 1720 2nd Ave. S. FOT 1203, Birmingham, AL 35294-3412, United States. jdr25@uab.edu
Key Words	Yttrium-90 microspheres; Liver metastases; Multivariate analysis; Toxicity incidence; Colorectal adenocarcinoma
Core Tip	Factors associated with the development of severe (grade ≥ 3) toxicities were identified using multivariate logistic regression models using Common Terminology Criteria for Adverse Events version 4.03. We found that severe toxicities were present following 21.5% of treatments. Abnormal pre-treatment albumin and international normalized ratio (INR) were associated with development of severe hepatic toxicity. Abnormal pre-treatment aspartate aminotransferase (AST) and hemoglobin were associated with development of severe albumin toxicity. Increasing pre-treatment model for end-stage liver disease (MELD) was associated with severe total bilirubin toxicity, and colorectal adenocarcinoma with severe alkaline phosphatase toxicity. Pre-treatment albumin, INR, AST, hemoglobin, MELD, and colorectal histology should be considered when selecting appropriate candidates for 90Y microsphere therapy.
Publish Date	2016-03-04 19:53
Citation	Roberson JD, McDonald AM, Baden CJ, Lin CP, Jacob R, Burnett OL. Factors associated with increased incidence of severe toxicities following yttrium-90 resin microspheres in the treatment of hepatic malignancies. World J Gastroenterol 2016; 22(10): 3006-3014
URL	http://www.wjgnet.com/1007-9327/full/v22/i10/3006.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i10.3006

Full Article (PDF)	WJG-22-3006.pdf
Full Article (Word)	WJG-22-3006.doc
Manuscript File	22177-Review.docx
Answering Reviewers	22177-Answering reviewers.pdf
Audio Core Tip	22177-Audio core tip.mp3
Biostatistics Review Certificate	22177-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form	22177-Conflict-of-interest statement.pdf
Copyright License Agreement	22177-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150818045545.pdf
Institutional Review Board Approval Form or Document	22177-Institutional review board statement.pdf
Supplementary Material	22177-Supplementary material.pdf
Peer-review Report	22177-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22177-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22177-Scientific misconduct check.pdf
Scientific Editor Work List	22177-Scientific editor work list.pdf