Publication Name	World Journal of Radiology
Manuscript ID	22239
Country	United Kingdom

Received	2015-08-22 17:16
Peer-Review Started	2015-08-24 10:55
To Make the First Decision	2015-09-28 11:55
Return for Revision	2015-09-30 15:29
Revised	2015-10-10 14:31
Second Decision	2015-11-27 16:03
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-08 15:33
Articles in Press	2015-12-08 15:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-20 16:11
Publish the Manuscript Online	2016-01-26 17:37

ISSN	1949-8470 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Radiology, Nuclear Medicine & Medical Imaging
Manuscript Type	Review
Article Title	Diffusion-weighted magnetic resonance imaging in cancer: Reported apparent diffusion coefficients, in-vitro and in-vivo reproducibility
Manuscript Source	Invited Manuscript
All Author List	Maysam M Jafar, Arman Parsai and Marc E Miquel
Funding Agency and Grant Number
Corresponding Author	Maysam M Jafar, PhD, Clinical Physics, Barts Health NHS Trust, West Smithfield, London EC1A 7BE, United Kingdom. maysam.jafar@nhs.net
Key Words	Diffusion-weighted magnetic resonance imaging; Apparent diffusion coefficient reproducibility; Apparent diffusion coefficient; Cancer imaging; Extra-cranial organs
Core Tip	Diffusion-weighted magnetic resonance imaging was highlighted as a potential cancer imaging biomarker by a team of experts in a report published in 2009. We review the variability of published diffusion values in the major extra-cranial organs and focus on the validation literature, both in vivo and in vitro. A total of 115 studies were selected including for liver parenchyma, kidney, pancreatic body, spleen, gallbladder, prostate, uterus (endometrium, myometrium, cervix) and breast. We also look in detail at the published repeatability and reproducibility studies, both in vivo and in phantoms. A series of recommendations based on our findings are given at the end of this review.
Publish Date	2016-01-26 17:37
Citation	Jafar MM, Parsai A, Miquel ME. Diffusion-weighted magnetic resonance imaging in cancer: Reported apparent diffusion coefficients, in vitro and in vivo reproducibility. World J Radiol 2016; 8(1): 21-49
URL	http://www.wjgnet.com/1949-8470/full/v8/i1/21.htm
DOI	http://dx.doi.org/10.4329/wjr.v8.i1.21

Full Article (PDF)	WJR-8-21.pdf
Full Article (Word)	WJR-8-21.doc
Manuscript File	22239-Review.docx
Answering Reviewers	22239-Answering reviewers.pdf
Audio Core Tip	22239-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22239-Conflict-of-interest statement.pdf
Copyright License Agreement	22239-Copyright assignment.pdf
Peer-review Report	22239-Peer-review(s).pdf
Scientific Misconduct Check	22239-Scientific misconduct check.pdf
Scientific Editor Work List	22239-Scientific editor work list.pdf