Publication Name	World Journal of Gastroenterology
Manuscript ID	2225
Country	China

Received	2013-02-07 20:44
Peer-Review Started	2013-02-10 20:04
To Make the First Decision	2013-03-04 10:41
Return for Revision	2013-03-04 15:08
Revised
Second Decision	2013-05-07 17:40
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2013-05-08 09:16
Articles in Press
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-06-09 16:21
Publish the Manuscript Online	2013-06-28 23:55

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Relationship between hepatocellular carcinoma and hepatitis B virus genotype with spontaneous YMDD mutations
Manuscript Source	Invited Manuscript
All Author List	Jia-Hong Yang, Hao Zhang, Xue-Bing Chen, Gao Chen and Xiu Wang
Funding Agency and Grant Number	Funding Agency Grant Number Health Bureau of Sichuan Province, China 070283 Health Bureau of Sichuan Province, China 100175
Corresponding Author	Jia-Hong Yang, MD, Department of Infectious Diseases, People's Hospital of Deyang City, No. 173, Taishan North Road, Deyang 618000, Sichuan Province, China. 18990283956@163.com
Key Words	Hepatitis B virus; Liver cirrhosis; Primary hepatocellular carcinoma; Hepatitis B virus genotype; YMDD mutation
Core Tip	YMDD mutation is a research hotspot globally. Until recently, most research about YMDD mutation focused on the occurrence of lamivudine-related YMDD mutation and its impact on antiviral treatment. In our research, 264 hepatitis B virus (HBV)-related liver cirrhosis patients not treated with antiviral drugs, including 81 with primary hepatocellular carcinoma (HCC), were investigated for the association between infection by different HBV genotype strains with spontaneous YMDD mutations and occurrence of primary HCC in cirrhosis patients. Infection by genotype C strains with spontaneous YMDD mutations is an independent risk factor for the development of HCC in cirrhosis patients.
Publish Date	2013-06-28 23:55
Citation	Yang JH, Zhang H, Chen XB, Chen G, Wang X. Relationship between hepatocellular carcinoma and hepatitis B virus genotype with spontaneous YMDD mutations. World J Gastroenterol 2013; 19(24): 3861-3865
URL	http://www.wjgnet.com/1007-9327/full/v19/i24/3861.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i24.3861

Full Article (PDF)	WJG-19-3861.pdf
Manuscript File	2225-Review.doc
Answering Reviewers	2225-Answering reviewers.doc
Copyright License Agreement	2225-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	2225-Language certificate.doc
Peer-review Report	2225-Peer review(s).pdf
Scientific Editor Work List	2225-Scientific editor work list.doc