Publication Name	World Journal of Stem Cells
Manuscript ID	22305
Country	France

Received	2015-08-25 13:38
Peer-Review Started	2015-08-28 19:55
To Make the First Decision	2015-10-27 10:43
Return for Revision	2015-10-30 10:09
Revised	2015-11-09 00:27
Second Decision	2015-11-23 18:01
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-14 17:55
Articles in Press	2015-12-14 17:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-12 09:00
Publish the Manuscript Online	2016-01-19 13:45

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Oncology
Manuscript Type	Minireviews
Article Title	Targeting head and neck tumoral stem cells: From biological aspects to therapeutic perspectives
Manuscript Source	Invited Manuscript
All Author List	Benoîte Méry, Jean-Baptiste Guy, Sophie Espenel, Anne-Sophie Wozny, Stéphanie Simonet, Alexis Vallard, Gersende Alphonse, Dominique Ardail, Claire Rodriguez-Lafrasse and Nicolas Magné
Funding Agency and Grant Number
Corresponding Author	Nicolas Magné, MD, PhD, Department of Radiotherapy, Lucien Neuwirth Cancer Institute, 108 bis, Avenue Albert Raimond, BP 60008, 42271 Saint-Priest en Jarez, France. nicolas.magne@icloire.fr
Key Words	Biology; Head and neck neoplasms; Oral cancer; Neoplastic stem cells; Molecular targeted therapy; Radiation therapy; Chemotherapy
Core Tip	The cancer stem cells (CSCs) theory offers an insight into why currently available therapies for head and neck cancer fail so often. Eradication of cancers may require the targeting and elimination of CSCs, especially for head and neck squamous cell cancer (HNSCC). This represents a challenge because many pathways, such as those involved in self-renewal, are shared by CSCs and their normal counterparts and might lead to major toxicities. Developing radio sensitizing strategies is investigated and appears to eliminate CSCs. Overcoming chemo resistance, radio resistance and immune evasion mechanisms of CSCs remains a cornerstone of novel adjuvant therapies specifically targeting CSCs in HNSCC.
Publish Date	2016-01-19 13:45
Citation	Méry B, Guy JB, Espenel S, Wozny AS, Simonet S, Vallard A, Alphonse G, Ardail D, Rodriguez-Lafrasse C, Magné N. Targeting head and neck tumoral stem cells: From biological aspects to therapeutic perspectives. World J Stem Cells 2016; 8(1): 13-21
URL	http://www.wjgnet.com/1948-0210/full/v8/i1/13.htm
DOI	http://dx.doi.org/10.4252/wjsc.v8.i1.13

Full Article (PDF)	WJSC-8-13.pdf
Full Article (Word)	WJSC-8-13.doc
Manuscript File	22305-Review.doc
Answering Reviewers	22305-Answering reviewers.pdf
Audio Core Tip	22305-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22305-Conflict-of-interest statement.pdf
Copyright License Agreement	22305-Copyright assignment.pdf
Peer-review Report	22305-Peer-review(s).pdf
Scientific Misconduct Check	22305-Scientific misconduct check.pdf
Scientific Editor Work List	22305-Scientific editor work list.pdf