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1/19/2016 1:44:00 PM | Browse: 1005 | Download: 1131
Publication Name World Journal of Stem Cells
Manuscript ID 22305
Country/Territory France
Received
2015-08-25 13:38
Peer-Review Started
2015-08-28 19:55
To Make the First Decision
2015-10-27 10:43
Return for Revision
2015-10-30 10:09
Revised
2015-11-09 00:27
Second Decision
2015-11-23 18:01
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-12-14 17:55
Articles in Press
2015-12-14 17:55
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-01-12 09:00
Publish the Manuscript Online
2016-01-19 13:45
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Oncology
Manuscript Type Minireviews
Article Title Targeting head and neck tumoral stem cells: From biological aspects to therapeutic perspectives
Manuscript Source Invited Manuscript
All Author List Benoîte Méry, Jean-Baptiste Guy, Sophie Espenel, Anne-Sophie Wozny, Stéphanie Simonet, Alexis Vallard, Gersende Alphonse, Dominique Ardail, Claire Rodriguez-Lafrasse and Nicolas Magné
Funding Agency and Grant Number
Corresponding Author Nicolas Magné, MD, PhD, Department of Radiotherapy, Lucien Neuwirth Cancer Institute, 108 bis, Avenue Albert Raimond, BP 60008, 42271 Saint-Priest en Jarez, France. nicolas.magne@icloire.fr
Key Words Biology; Head and neck neoplasms; Oral cancer; Neoplastic stem cells; Molecular targeted therapy; Radiation therapy; Chemotherapy
Core Tip The cancer stem cells (CSCs) theory offers an insight into why currently available therapies for head and neck cancer fail so often. Eradication of cancers may require the targeting and elimination of CSCs, especially for head and neck squamous cell cancer (HNSCC). This represents a challenge because many pathways, such as those involved in self-renewal, are shared by CSCs and their normal counterparts and might lead to major toxicities. Developing radio sensitizing strategies is investigated and appears to eliminate CSCs. Overcoming chemo resistance, radio resistance and immune evasion mechanisms of CSCs remains a cornerstone of novel adjuvant therapies specifically targeting CSCs in HNSCC.
Publish Date 2016-01-19 13:45
Citation Méry B, Guy JB, Espenel S, Wozny AS, Simonet S, Vallard A, Alphonse G, Ardail D, Rodriguez-Lafrasse C, Magné N. Targeting head and neck tumoral stem cells: From biological aspects to therapeutic perspectives. World J Stem Cells 2016; 8(1): 13-21
URL http://www.wjgnet.com/1948-0210/full/v8/i1/13.htm
DOI http://dx.doi.org/10.4252/wjsc.v8.i1.13
Full Article (PDF) WJSC-8-13.pdf
Full Article (Word) WJSC-8-13.doc
Manuscript File 22305-Review.doc
Answering Reviewers 22305-Answering reviewers.pdf
Audio Core Tip 22305-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 22305-Conflict-of-interest statement.pdf
Copyright License Agreement 22305-Copyright assignment.pdf
Peer-review Report 22305-Peer-review(s).pdf
Scientific Misconduct Check 22305-Scientific misconduct check.pdf
Scientific Editor Work List 22305-Scientific editor work list.pdf