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Articles Published Processes
4/11/2016 10:17:00 AM | Browse: 952 | Download: 1978
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Received |
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2015-08-25 13:30 |
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Peer-Review Started |
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2015-08-27 16:01 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2015-10-30 10:09 |
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Revised |
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2015-11-12 10:29 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2015-12-07 09:31 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2015-12-14 17:56 |
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Articles in Press |
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2015-12-14 17:56 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-03-31 15:53 |
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Publish the Manuscript Online |
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2016-04-11 10:17 |
| ISSN |
2220-6132 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Minireviews |
| Article Title |
Naked DNA in cells: An inducer of major histocompatibility complex molecules to evoke autoimmune responses?
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yuqian Luo, Aya Yoshihara, Kenzaburo Oda, Yuko Ishido, Naoki Hiroi and Koichi Suzuki |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Scientific Research from the Japan Society for the Promotion of Science to Suzuki K |
15K09444 |
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| Corresponding Author |
Koichi Suzuki, Professor, Department of Clinical Laboratory Science, Faculty of Medical Technology, Teikyo University, 2-11-2 Kaga, Itabashi, Tokyo 173-8605, Japan. koichis0923@med.teikyo-u.ac.jp
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| Key Words |
Cytosolic double-stranded DNA; Major histocompatibility complex molecules; Autoimmune response; Antigen presentation; Tissue injury |
| Core Tip |
We reviewed the discovery of an unexpected effect of cytosolic double-stranded DNA (dsDNA) to induce antigen processing and presenting genes including major histocompatibility complex (MHC) molecules in non-immune cells. We also focus on the current status quo of the overall research in the field with highlight on our recent findings that suggest cell injury-induced self-cytosolic dsDNA is a potential trigger in the development of autoimmunity. Meanwhile, we provide in-depth discussion of the molecular signals responsible for the effect of dsDNA to induce MHC molecules, based on the current opinion of dsDNA-mediated signal pathways.
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| Publish Date |
2016-04-11 10:17 |
| Citation |
Luo Y, Yoshihara A, Oda K, Ishido Y, Hiroi N, Suzuki K. Naked DNA in cells: An inducer of major histocompatibility complex molecules to evoke autoimmune responses? World J Transl Med 2016; 5(1): 46-52 |
| URL |
http://www.wjgnet.com/2220-6132/full/v5/i1/46.htm |
| DOI |
http://dx.doi.org/10.5528/wjtm.v5.i1.46 |
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