Publication Name	World Journal of Translational Medicine
Manuscript ID	22310
Country	Japan

Received	2015-08-25 13:30
Peer-Review Started	2015-08-27 16:01
To Make the First Decision	2015-10-27 10:43
Return for Revision	2015-10-30 10:09
Revised	2015-11-12 10:29
Second Decision	2015-12-07 09:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2015-12-14 17:56
Articles in Press	2015-12-14 17:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-31 15:53
Publish the Manuscript Online	2016-04-11 10:17

ISSN	2220-6132 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Immunology
Manuscript Type	Minireviews
Article Title	Naked DNA in cells: An inducer of major histocompatibility complex molecules to evoke autoimmune responses?
Manuscript Source	Invited Manuscript
All Author List	Yuqian Luo, Aya Yoshihara, Kenzaburo Oda, Yuko Ishido, Naoki Hiroi and Koichi Suzuki
Funding Agency and Grant Number	Funding Agency Grant Number Scientific Research from the Japan Society for the Promotion of Science to Suzuki K 15K09444
Corresponding Author	Koichi Suzuki, Professor, Department of Clinical Laboratory Science, Faculty of Medical Technology, Teikyo University, 2-11-2 Kaga, Itabashi, Tokyo 173-8605, Japan. koichis0923@med.teikyo-u.ac.jp
Key Words	Cytosolic double-stranded DNA; Major histocompatibility complex molecules; Autoimmune response; Antigen presentation; Tissue injury
Core Tip	We reviewed the discovery of an unexpected effect of cytosolic double-stranded DNA (dsDNA) to induce antigen processing and presenting genes including major histocompatibility complex (MHC) molecules in non-immune cells. We also focus on the current status quo of the overall research in the field with highlight on our recent findings that suggest cell injury-induced self-cytosolic dsDNA is a potential trigger in the development of autoimmunity. Meanwhile, we provide in-depth discussion of the molecular signals responsible for the effect of dsDNA to induce MHC molecules, based on the current opinion of dsDNA-mediated signal pathways.
Publish Date	2016-04-11 10:17
Citation	Luo Y, Yoshihara A, Oda K, Ishido Y, Hiroi N, Suzuki K. Naked DNA in cells: An inducer of major histocompatibility complex molecules to evoke autoimmune responses? World J Transl Med 2016; 5(1): 46-52
URL	http://www.wjgnet.com/2220-6132/full/v5/i1/46.htm
DOI	http://dx.doi.org/10.5528/wjtm.v5.i1.46

Full Article (PDF)	WJTM-5-46.pdf
Full Article (Word)	WJTM-5-46.doc
Manuscript File	22310-Review.docx
Answering Reviewers	22310-Answering reviewers.pdf
Audio Core Tip	22310-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22310-Conflict-of-interest statement.PDF
Copyright License Agreement	22310-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	22310-Language certificat.pdf
Peer-review Report	22310-Peer-review(s).pdf
Scientific Misconduct Check	22310-Scientific misconduct check.pdf
Scientific Editor Work List	22310-Scientific editor work list.pdf