Publication Name	World Journal of Hepatology
Manuscript ID	22364
Country	Saudi Arabia

Received	2015-08-27 08:38
Peer-Review Started	2015-08-31 12:06
To Make the First Decision	2015-10-08 16:17
Return for Revision	2015-10-19 01:20
Revised	2015-11-16 22:44
Second Decision	2016-02-22 11:28
Accepted by Journal Editor-in-Chief	2016-02-22 21:37
Accepted by Executive Editor-in-Chief	2016-04-11 11:43
Articles in Press	2016-04-11 17:20
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-04-13 14:44
Publish the Manuscript Online	2016-04-19 14:32

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Website	http://www.wjgnet.com

Category	Virology
Manuscript Type	Review
Article Title	Hepatitis C virus and neurological damage
Manuscript Source	Invited Manuscript
All Author List	Shilu Mathew, Muhammed Faheem, Sara M Ibrahim, Waqas Iqbal, Bisma Rauff, Kaneez Fatima and Ishtiaq Qadri
Funding Agency and Grant Number	Funding Agency Grant Number KACST large R and D grant to Ishtiaq Qadri 162-34
Corresponding Author	Ishtiaq Qadri, Professor, King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 80200, Jeddah 21589, Saudi Arabia. ishtiaq80262@yahoo.com
Key Words	Hepatitis C virus; Neuro disorders; Blood brain barrier; Nervous system; Inflammation
Core Tip	There is high prevalence rate of neuropsy-chiatric ailments with respect to patients infected with chronic hepatitis C virus (HCV). Brain inflammatory disorders, cerebrovascular disease peripheral neuro-pathy, psychiatric disturbs and cognitive symptoms are the complex clinical signs which occurs when infected by chronic HCV infection. HCV prompts psychiatric and neurological symptoms through numerous pathways with imprecise mechanisms, which includes neurotransmitter and metabolic pathway imbalance, immune-mediated responses and direct brain neurotoxicity inflammation. Awareness of HCV-associated neuropsychiatric disorders and its pathogenic mechanisms is vital to understand the clinical manifestations and to introduce an applicable treatment.
Publish Date	2016-04-19 14:32
Citation	Mathew S, Faheem M, Ibrahim SM, Iqbal W, Rauff B, Fatima K, Qadri I. Hepatitis C virus and neurological damage. World J Hepatol 2016; 8(12): 545-556
URL	http://www.wjgnet.com/1948-5182/full/v8/i12/545.htm
DOI	http://dx.doi.org/10.4254/wjh.v8.i12.545

Full Article (PDF)	WJH-8-545.pdf
Full Article (Word)	WJH-8-545.doc
Manuscript File	22364-Review.doc
Answering Reviewers	22364-Answering reviewers.pdf
Audio Core Tip	22364-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22364-Conflict-of-interest statement.pdf
Copyright License Agreement	22364-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	22364-Grant application form(s).pdf
Peer-review Report	22364-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22364-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22364-Scientific misconduct check.pdf
Scientific Editor Work List	22364-Scientific editor work list.pdf