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Articles Published Processes
3/1/2016 2:39:00 PM | Browse: 887 | Download: 1790
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Received |
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2015-08-28 09:50 |
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Peer-Review Started |
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2015-08-31 21:38 |
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To Make the First Decision |
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2015-09-28 12:09 |
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Return for Revision |
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2015-10-10 09:55 |
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Revised |
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2015-11-05 15:08 |
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Second Decision |
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2015-12-15 08:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-12-20 16:01 |
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Articles in Press |
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2015-12-20 16:01 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-02-18 09:42 |
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Publish the Manuscript Online |
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2016-03-01 14:46 |
| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Urology & Nephrology |
| Manuscript Type |
Observational Study |
| Article Title |
Matrix metalloproteinase-2 as a superior biomarker for peritoneal deterioration in peritoneal dialysis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ichiro Hirahara, Eiji Kusano, Yoshiyuki Morishita, Makoto Inoue, Tetsu Akimoto, Osamu Saito, Shigeaki Muto and Daisuke Nagata |
| Funding Agency and Grant Number |
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| Corresponding Author |
Dr. Ichiro Hirahara, Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke, Tochigi 329-0498, Japan. hirahara@rpf.jp |
| Key Words |
Encapsulating peritoneal sclerosis; Matrix metalloproteinase-2; Peritoneal dialysis; Peritoneal solute transport; Peritoneal deterioration |
| Core Tip |
Peritoneal effluent samples were obtained from 218 peritoneal dialysis (PD) patients with end-stage renal disease at 18 centers. The effluent levels of biomarkers matrix metalloproteinase-2 (MMP-2), interleukin-6, hyaluronan, and cancer antigen 125 were measured. Peritoneal solute transport rate was assessed by peritoneal equilibration test (PET) to estimate peritoneal deterioration. Among the biomarkers in the effluent, MMP-2 level correlated most significantly with peritoneal solute transport rate. The area under the receiver operating characteristic curve analysis for effluent MMP-2 level against high PET category was 0.90. MMP-2 may be a superior biomarker for peritoneal deterioration during PD. |
| Publish Date |
2016-03-01 14:46 |
| Citation |
Hirahara I, Kusano E, Morishita Y, Inoue M, Akimoto T, Saito O, Muto S, Nagata D. Matrix metalloproteinase-2 as a superior biomarker for peritoneal deterioration in peritoneal dialysis. World J Nephrol 2016; 5(2): 204-212 |
| URL |
http://www.wjgnet.com/2220-6124/full/v5/i2/204.htm |
| DOI |
http://dx.doi.org/10.5527/wjn.v5.i2.204 |
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