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Articles Published Processes
1/6/2016 8:46:00 PM | Browse: 1225 | Download: 1898
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Received |
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2015-09-09 17:34 |
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Peer-Review Started |
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2015-09-10 15:54 |
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First Decision by Editorial Office Director |
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Return for Revision |
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2015-10-16 14:29 |
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Revised |
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2015-10-21 19:19 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2015-12-03 17:37 |
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Second Decision by Editor-in-Chief |
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2015-12-04 19:25 |
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Final Decision by Editorial Office Director |
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2015-12-11 16:06 |
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Articles in Press |
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2015-12-11 16:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-01-04 19:17 |
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Publish the Manuscript Online |
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2016-01-06 20:46 |
| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Minireviews |
| Article Title |
Role of calcium in polycystic kidney disease: From signaling to pathology
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Alessandra Mangolini, Lucia de Stephanis and Gianluca Aguiari |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| University of Ferrara local funds: FAR 2012, 2013, 2014 |
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| Regione Emilia Romagna grant (Ricerca Regione-Università) 2007-2009 |
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| Corresponding Author |
Gianluca Aguiari, PhD, Department of Biomedical and Surgical Specialty Sciences, Section of Biochemistry, Molecular Biology and Medical Genetics, University of Ferrara, via Fossato di Mortara 74, 44121 Ferrara, Italy. dsn@unife.it |
| Key Words |
Autosomal dominant polycystic kidney disease; Calcium signaling; cAMP; Cell growth; Non-capacitative calcium entry |
| Core Tip |
In the present article, we discuss: (1) the regulation of calcium signaling in the primary cilia of autosomal dominant polycystic kidney disease (ADPKD) cells and the downstream processes that lead to cystogenesis; (2) how calcium impairment promotes cell proliferation by activating different signaling pathways; (3) the activity of non-capacitative calcium entry channels, which in PKD1-silenced cells stimulates cell growth by Ca2+ oscillations and nuclear factor of activated T-cells activation, highlighting new findings showing the role of polycystin-2 in calcium oscillations; (4) the impairment of intracellular calcium signaling associated with apoptosis; and (5) the use of calcium channel blockers and calcium modulators in the treatment of ADPKD. |
| Publish Date |
2016-01-06 20:46 |
| Citation |
Mangolini A, de Stephanis L, Aguiari G. Role of calcium in polycystic kidney disease: From signaling to pathology. World J Nephrol 2016; 5(1): 76-83 |
| URL |
http://www.wjgnet.com/2220-6124/full/v5/i1/76.htm |
| DOI |
http://dx.doi.org/10.5527/wjn.v5.i1.76 |
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