Publication Name	World Journal of Nephrology
Manuscript ID	22395
Country	Italy

Received	2015-09-09 17:34
Peer-Review Started	2015-09-10 15:54
To Make the First Decision	2015-10-08 15:55
Return for Revision	2015-10-16 14:29
Revised	2015-10-21 19:19
Second Decision	2015-12-03 17:37
Accepted by Journal Editor-in-Chief	2015-12-04 19:25
Accepted by Company Editor-in-Chief	2015-12-11 16:06
Articles in Press	2015-12-11 16:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-04 19:17
Publish the Manuscript Online	2016-01-06 20:46

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	Role of calcium in polycystic kidney disease: From signaling to pathology
Manuscript Source	Invited Manuscript
All Author List	Alessandra Mangolini, Lucia de Stephanis and Gianluca Aguiari
Funding Agency and Grant Number	Funding Agency Grant Number University of Ferrara local funds: FAR 2012, 2013, 2014 Regione Emilia Romagna grant (Ricerca Regione-Università) 2007-2009
Corresponding Author	Gianluca Aguiari, PhD, Department of Biomedical and Surgical Specialty Sciences, Section of Biochemistry, Molecular Biology and Medical Genetics, University of Ferrara, via Fossato di Mortara 74, 44121 Ferrara, Italy. dsn@unife.it
Key Words	Autosomal dominant polycystic kidney disease; Calcium signaling; cAMP; Cell growth; Non-capacitative calcium entry
Core Tip	In the present article, we discuss: (1) the regulation of calcium signaling in the primary cilia of autosomal dominant polycystic kidney disease (ADPKD) cells and the downstream processes that lead to cystogenesis; (2) how calcium impairment promotes cell proliferation by activating different signaling pathways; (3) the activity of non-capacitative calcium entry channels, which in PKD1-silenced cells stimulates cell growth by Ca2+ oscillations and nuclear factor of activated T-cells activation, highlighting new findings showing the role of polycystin-2 in calcium oscillations; (4) the impairment of intracellular calcium signaling associated with apoptosis; and (5) the use of calcium channel blockers and calcium modulators in the treatment of ADPKD.
Publish Date	2016-01-06 20:46
Citation	Mangolini A, de Stephanis L, Aguiari G. Role of calcium in polycystic kidney disease: From signaling to pathology. World J Nephrol 2016; 5(1): 76-83
URL	http://www.wjgnet.com/2220-6124/full/v5/i1/76.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i1.76

Full Article (PDF)	WJN-5-76.pdf
Full Article (Word)	WJN-5-76.doc
Manuscript File	22395-Review.doc
Answering Reviewers	22395-Answering reviewers.pdf
Audio Core Tip	22395-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22395-Conflict-of-interest statement.pdf
Copyright License Agreement	22395-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	22395-Language certificate.pdf
Peer-review Report	22395-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22395-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22395-Scientific misconduct check.pdf
Scientific Editor Work List	22395-Scientific editor work list.pdf