Publication Name	World Journal of Stem Cells
Manuscript ID	22431
Country	United Kingdom

Received	2015-08-29 17:19
Peer-Review Started	2015-09-04 12:10
To Make the First Decision	2015-11-24 14:46
Return for Revision	2015-11-27 17:23
Revised	2015-12-11 06:04
Second Decision	2016-01-20 16:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2016-01-29 17:34
Articles in Press	2016-01-29 17:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-18 13:50
Publish the Manuscript Online	2016-02-23 14:18

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Medicine, Research & Experimental
Manuscript Type	Minireviews
Article Title	Use of platelet lysate for bone regeneration - are we ready for clinical translation?
Manuscript Source	Invited Manuscript
All Author List	Ala Altaie, Heather Owston and Elena Jones
Funding Agency and Grant Number	Funding Agency Grant Number Leeds Musculoskeletal Biomedical Research Unit to Elena Jones EPSRC to Heather Owston
Corresponding Author	Elena Jones, PhD, Associate Professor in Stem Cell Biology, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, St. James’s University Hospital, Beckett Street, Leeds LS9 7TF, United Kingdom. msjej@leeds.ac.uk
Key Words	Mesenchymal stem cells; Platelet lysate; Bone regeneration
Core Tip	Human platelet lysate (PL) offers an exciting opportunity for expanding mesenchymal stem cells (MSCs), as well as for use in bone regeneration as a scaffold coating. In this review, we describe the state-of-the-art research in the area of bone regeneration utilising PL and MSCs and emphasise the need for standardisation of PL preparation and its quality control in order to progress further in this exciting area of research. Different PL formulations could be tailor-made for specific scaffolds and bone repair indications, both in autologous and allogenic settings. More pre-clinical and clinical work is needed to progress this research into clinical translation.
Publish Date	2016-02-23 14:18
Citation	Altaie A, Owston H, Jones E. Use of platelet lysate for bone regeneration - are we ready for clinical translation? World J Stem Cells 2016; 8(2): 47-55
URL	http://www.wjgnet.com/1948-0210/full/v8/i2/47.htm
DOI	http://dx.doi.org/10.4252/wjsc.v8.i2.47

Full Article (PDF)	WJSC-8-47.pdf
Full Article (Word)	WJSC-8-47.doc
Manuscript File	22431-Review.docx
Answering Reviewers	22431-Answering reviewers.pdf
Audio Core Tip	22431-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22431-Conflict-of-interest statement.pdf
Copyright License Agreement	22431-Copyright assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	22431-Grant application form(s).pdf
Peer-review Report	22431-Peer-review(s).pdf
Scientific Misconduct Check	22431-Scientific misconduct check.pdf
Scientific Editor Work List	22431-Scientific editor work list.pdf