Publication Name	World Journal of Psychiatry
Manuscript ID	22436
Country	Spain

Received	2015-08-29 17:13
Peer-Review Started	2015-09-04 13:28
To Make the First Decision	2015-09-28 12:09
Return for Revision	2015-10-10 10:54
Revised	2015-11-08 19:31
Second Decision	2016-01-18 19:43
Accepted by Journal Editor-in-Chief	2016-01-18 22:28
Accepted by Executive Editor-in-Chief	2016-01-22 16:25
Articles in Press	2016-01-22 16:25
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-03-03 17:39
Publish the Manuscript Online	2016-03-16 12:23

ISSN	2220-3206 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Psychiatry
Manuscript Type	Review
Article Title	Are the changes in the peripheral brain-derived neurotrophic factor levels due to platelet activation?
Manuscript Source	Invited Manuscript
All Author List	Montserrat Serra-Millàs
Funding Agency and Grant Number
Corresponding Author	Montserrat Serra-Millàs, PhD, Osona Mental Health, Hospital Universitari de Vic, Salut Mental i Innovació Social (SaMIS), Universitat de Vic-Universitat Central de Catalunya, C/Francesc Pla «El Vigatà» nº 1, 08500 Vic, Barcelona, Spain. serra2mont@yahoo.es
Key Words	Platelets; Brain derived neurotrophic factor; Depression; Antidepressants; Biomarkers
Core Tip	Brain-derived neurotrophic factor (BDNF) is expressed in neuronal and non- neuronal tissues and is stored peripherally in platelets. Platelet BDNF is present in α-granules and cytoplasm and only BDNF of granules is released by agonist stimulation. Little is known about mechanisms related to BDNF release in human platelets. Depressive disorders are associated with BDNF and platelet dysfunction. Low levels of serum BDNF have been described in major depression and they increased with antidepressant treatment. Only a few studies have evaluated the relationship between platelet activation and peripheral BDNF values. This review suggests that platelet reactivity may partly explain the alterations in BDNF.
Publish Date	2016-03-16 12:23
Citation	Serra-Millàs M. Are the changes in the peripheral brain-derived neurotrophic factor levels due to platelet activation? World J Psychiatr 2016; 6(1): 84-101
URL	http://www.wjgnet.com/2220-3206/full/v6/i1/84.htm
DOI	http://dx.doi.org/10.5498/wjp.v6.i1.84

Full Article (PDF)	WJP-6-84.pdf
Full Article (Word)	WJP-6-84.doc
Manuscript File	22436-Review.doc
Answering Reviewers	22436-Answering reviewers.pdf
Audio Core Tip	22436-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22436-Conflict-of-interest statement.pdf
Copyright License Agreement	22436-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	22436-Language certificate.pdf
Peer-review Report	22436-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22436-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22436-Scientific misconduct check.pdf
Scientific Editor Work List	22436-Scientific editor work list.pdf