Publication Name	World Journal of Gastroenterology
Manuscript ID	2248
Country	Italy

Received	2013-02-09 17:06
Peer-Review Started	2013-02-13 13:23
First Decision by Editorial Office Director
Return for Revision	2013-03-18 09:58
Revised	2013-04-18 00:51
Publication Fee Transferred
Second Decision by Editor	2013-05-09 12:48
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2013-05-10 10:25
Articles in Press
Edit the Manuscript by Language Editor
Typeset the Manuscript	2013-07-04 14:20
Publish the Manuscript Online	2013-07-20 20:47

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Autobiography
Article Title	Phytoestrogens/insoluble fibers and colonic estrogen receptor β: Randomized, double-blind, placebo-controlled study
Manuscript Source	Invited Manuscript
All Author List	Mariabeatrice Principi, Alfredo Di Leo, Maria Pricci, Maria Principia Scavo, Raffaella Guido, Sabina Tanzi, Domenico Piscitelli, Antonio Pisani, Enzo Ierardi, Maria Cristina Comelli and Michele Barone
Funding Agency and Grant Number	Funding Agency Grant Number Wholly granted from R and D, CMD Pharma Limited, United Kingdom
Corresponding Author	Alfredo Di Leo, Professor, Chief of Gastroenterology Unit, Department of Emergency and Organ Transplantation, University of Bari, Piazza Giulio Cesare 11, 70124 Bari, Italy. b.principi@gmail.com
Key Words	Estrogen receptor-β; Estrogen receptor-α; Terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling; Sporadic adenomatous polyposis; Phytoestrogens; Insoluble fibers
Core Tip	Active dietary intervention, a mixture of phytoestrogens and insoluble fibers, was administered in patients with sporadic colonic adenomas in a randomized, double-blind placebo-controlled trial. Dietary supplementation induced an increase in estrogen receptor (ER)-β protein and the ER-β/ER-α ratio with a general trend towards an increase in epithelial proliferation and apoptosis. These results, even if limited by the small number of subjects and short period of dietary supplementation, suggest the possibility of an interaction with epithelial apoptosis by means of mediating ER-β levels.
Publish Date	2013-07-20 20:47
Citation	Principi M, Di Leo A, Pricci M, Scavo MP, Guido R, Tanzi S, Piscitelli D, Pisani A, Ierardi E, Comelli MC, Barone M. Phytoestrogens/insoluble fibers and colonic estrogen receptor β: Randomized, double-blind, placebo-controlled study. World J Gastroenterol 2013; 19(27): 4325-4333
URL	http://www.wjgnet.com/1007-9327/full/v19/i27/4325.htm
DOI	http://dx.doi.org/10.3748/wjg.v19.i27.4325

Full Article (PDF)	WJG-19-4325.pdf
Manuscript File	2248-Review.doc
Answering Reviewers	2248-Answering reviewers.pdf
Copyright License Agreement	2248-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics Committee.doc
Non-Native Speakers of English Editing Certificate	2248-Language certificate.pdf
Peer-review Report	2248-Peer reviews.pdf