Publication Name	World Journal of Gastroenterology
Manuscript ID	22519
Country	Spain

Received	2015-09-26 14:48
Peer-Review Started	2015-09-28 13:43
First Decision by Editorial Office Director
Return for Revision	2015-10-18 16:07
Revised	2015-11-04 23:07
Publication Fee Transferred
Second Decision by Editor	2016-01-06 11:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2016-01-18 10:21
Articles in Press	2016-01-18 10:22
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-27 12:49
Publish the Manuscript Online	2016-03-14 08:44

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Hepatitis B and D viruses replication interference: Influence of hepatitis B genotype
Manuscript Source	Unsolicited Manuscript
All Author List	Antonio Madejón, Míriam Romero, Ángela Hernández, Araceli García-Sánchez, Marta Sánchez-Carrillo, Antonio Olveira and Javier García-Samaniego
Funding Agency and Grant Number	Funding Agency Grant Number “Fondo de Investigaciones Sanitarias” of the “Ministerio de Ciencia e Innovación” of Spain, with FEDER funds PI081486 Instituto de Salud Carlos III
Corresponding Author	Javier García-Samaniego, MD, PhD, Hepatology Section, Gastroenterology Department, Hospital Universitario La Paz, CIBERehd, Paseo de la Castellana 261, 28046 Madrid, Spain. javiersamaniego@telefonica.net
Key Words	Hepatitis D virus; Hepatitis b virus; Delta hepatitis; Replication interference; Viral replication
Core Tip	hepatitis b virus (HBV)-DNA titer is a predictive pattern of optimal response to treatment with interferon based regimens. Our results suggest that in chronic hepatitis delta patients the inhibition of HBV replication is genotype-dependent. Viral replication interference between HBV and hepatitis b virus (HDV) is more evident in patients infected with HBV-genotype A, than with HBV-D or E. Based on these results the analysis of HBV genotype could be taken into account in the algorithms for treatment indication for delta infected patients. For patients from geographical regions with a different distribution of HBV genotypes, the replication behaviour of HBV is warranted to clarify the HBV/HDV interference process.
Publish Date	2016-03-14 08:44
Citation	Madejón A, Romero M, Hernández A, García-Sánchez A, Sánchez-Carrillo M, Olveira A, García-Samaniego J. Hepatitis B and D viruses replication interference: Influence of hepatitis B genotype. World J Gastroenterol 2016; 22(11): 3165-3174
URL	http://www.wjgnet.com/1007-9327/full/v22/i11/3165.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i11.3165

Full Article (PDF)	WJG-22-3165.pdf
Full Article (Word)	WJG-22-3165.doc
Manuscript File	22519-Review.doc
Answering Reviewers	22519-Answering reviewers.pdf
Audio Core Tip	22519-Audio core tip.mp3
Biostatistics Review Certificate	22519-Biostatistics statement.pdf
Clinical Trial Registration Statement	DeclarationOf_HelsinkiConformation_Statement_20150925175659.pdf
Conflict-of-Interest Disclosure Form	22519-Conflict-of-interest statement.pdf
Copyright License Agreement	22519-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150925175707.pdf
Institutional Review Board Approval Form or Document	22519-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	22519-Language certificate.pdf
Peer-review Report	22519-Peer-review(s).pdf
Scientific Misconduct Check	22519-Scientific misconduct check.pdf
Scientific Editor Work List	22519-Scientific editor work list.pdf