Publication Name	World Journal of Gastroenterology
Manuscript ID	22542
Country	United States

Received	2015-09-02 08:34
Peer-Review Started	2015-09-02 17:53
To Make the First Decision	2015-10-14 16:57
Return for Revision	2015-10-21 14:34
Revised	2015-11-04 12:44
Second Decision	2015-11-09 16:09
Accepted by Journal Editor-in-Chief	2015-11-10 22:11
Accepted by Executive Editor-in-Chief	2015-11-24 17:28
Articles in Press	2015-11-24 17:28
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-12-01 09:11
Typeset the Manuscript	2015-12-29 12:53
Publish the Manuscript Online	2016-01-15 14:54

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Genetics & Heredity
Manuscript Type	Topic Highlights
Article Title	Application of computational methods in genetic study of inflammatory bowel disease
Manuscript Source	Invited Manuscript
All Author List	Jin Li, Zhi Wei and Hakon Hakonarson
Funding Agency and Grant Number
Corresponding Author	Zhi Wei, PhD, Associate Professor, Department of Computer Science, New Jersey Institute of Technology, Newark, NJ 07102, United States. zhiwei04@gmail.com
Key Words	Inflammatory bowel disease; Computational methods; Genome-wide association study; Pathway analysis; Gene-gene interaction; Gene-environment interaction; Pleiotropy; Risk prediction
Core Tip	Computational methods have rapidly progressed during the last a few years, which ren-dered us the ability to analyze genotype data on a genome-wide level. The application of these methods in inflammatory bowel disease (IBD) genetic study yielded productive results. We discuss the major types of analyses in genome-wide study, and the different computational methods used in each type of analysis. We also show how these computation methods were used in the IBD genetic study and the major findings achieved.
Publish Date	2016-01-15 14:54
Citation	Li J, Wei Z, Hakonarson H. Application of computational methods in genetic study of inflammatory bowel disease. World J Gastroenterol 2016; 22(3): 949-960
URL	http://www.wjgnet.com/1007-9327/full/v22/i3/949.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i3.949

Full Article (PDF)	WJG-22-949.pdf
Full Article (Word)	WJG-22-949.doc
Manuscript File	22542-Review.doc
Answering Reviewers	22542-Answering reviewers.pdf
Audio Core Tip	22542-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22542-Conflict-of-interest statement.pdf
Copyright License Agreement	22542-Copyright assignment.pdf
Peer-review Report	22542-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22542-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22542-Scientific misconduct check.pdf
Scientific Editor Work List	22542-Scientific editor work list.pdf