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3/4/2016 7:53:00 PM | Browse: 990 | Download: 1683
Publication Name World Journal of Gastroenterology
Manuscript ID 22550
Country/Territory China
Received
2015-09-16 08:51
Peer-Review Started
2015-09-16 13:13
To Make the First Decision
2015-10-14 17:59
Return for Revision
2015-10-15 13:57
Revised
2015-10-28 22:00
Second Decision
2015-11-10 08:46
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2015-11-19 13:30
Articles in Press
2015-11-19 13:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
2016-01-19 12:02
Typeset the Manuscript
2016-02-22 14:07
Publish the Manuscript Online
2016-03-04 19:53
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Effect of artesunate supplementation on bacterial translocation and dysbiosis of gut microbiota in rats with liver cirrhosis
Manuscript Source Unsolicited Manuscript
All Author List Yun-Xia Chen, Li-Na Lai, Hui-Ying Zhang, Yang-Hui Bi, Li Meng, Xu-Jiong Li, Xiao-Xia Tian, Li-Min Wang, Yi-Min Fan, Zhong-Fu Zhao, De-Wu Han and Cheng Ji
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81070339
International Science and Technology Cooperation Project of Shanxi 2010081068
Key Laboratory Foundation of Cellular Physiology Department of Shanxi Medical School and Provincial Ministry of Education 2010-09
Fund for Returned Students of Shanxi 211-091
Fund for Returned Medical Doctors of Changzhi Medical College 2010-01
Science and Technology Innovation Team Project of Changzhi Medical College CX201409
College Student Innovation and Entrepreneurship Training Project of Shanxi Province 2014308
US NIH R21AA023952(to Cheng Ji)
US NIH P30DK48522-21
Corresponding Author Hui-Ying Zhang, MD, Professor, Department of Pathophysiology, Changzhi Medical College, 161 Jiefang Dongjie, Changzhi 046000, Shanxi Province, China. zhanghy2001@163.com
Key Words Hepatic cirrhosis; Gut microbiota; Bacterial translocation; Artesunate; Intervention
Core Tip Artesunate (AS) is antimalarial yet potentially anti-inflammatory. We evaluated the effect of AS supplementation on bacterial translocation (BT) and the gut microbiota in a rat model of liver cirrhosis. Dysbiosis of gut microbiota, injury of intestinal mucosal barrier and BT occurred as liver cirrhosis progressed, which might enhance inflammation and aggravate liver injury. AS may have other non-antimalaria effects that modulate gut microbiota, inhibit BT and alleviate inflammation, leading to a reduction in carbon tetrachloride, alcohol and high fat-caused damages to the liver and intestine.
Publish Date 2016-03-04 19:53
Citation Chen YX, Lai LN, Zhang HY, Bi YH, Meng L, Li XJ, Tian XX, Wang LM, Fan YM, Zhao ZF, Han DW, Ji C. Effect of artesunate supplementation on bacterial translocation and dysbiosis of gut microbiota in rats with liver cirrhosis. World J Gastroenterol 2016; 22(10): 2949-2959
URL http://www.wjgnet.com/1007-9327/full/v22/i10/2949.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i10.2949
Full Article (PDF) WJG-22-2949.pdf
Full Article (Word) WJG-22-2949.doc
Manuscript File 22550-Review.doc
Answering Reviewers 22550-Answering reviewers.pdf
Audio Core Tip 22550-Audio core tip.mp3
Biostatistics Review Certificate 22550-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 22550-Conflict-of-interest statement.pdf
Copyright License Agreement 22550-Copyright assignment.pdf
Institutional Animal Care and Use Committee Approval Form or Document 22550-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 22550-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 22550-Language certificate.pdf
Peer-review Report 22550-Peer-review(s).pdf
Scientific Misconduct Check 22550-Scientific misconduct check.pdf
Scientific Editor Work List 22550-Scientific editor work list.pdf