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Articles Published Processes
3/4/2016 7:53:00 PM | Browse: 1173 | Download: 2322
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Received |
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2015-09-10 15:28 |
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Peer-Review Started |
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2015-09-17 09:01 |
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To Make the First Decision |
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2015-11-05 11:03 |
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Return for Revision |
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2015-11-06 15:43 |
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Revised |
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2015-11-22 20:49 |
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Second Decision |
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2015-12-11 07:56 |
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Accepted by Journal Editor-in-Chief |
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2015-12-11 16:57 |
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Accepted by Executive Editor-in-Chief |
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2015-12-21 14:05 |
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Articles in Press |
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2015-12-21 14:06 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-01-15 08:46 |
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Typeset the Manuscript |
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2016-02-24 11:07 |
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Publish the Manuscript Online |
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2016-03-04 19:53 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Synergistic anticancer properties of docosahexaenoic acid and 5-fluorouracil through interference with energy metabolism and cell cycle arrest in human gastric cancer cell line AGS cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Kun Gao, Qi Liang, Zhi-Hao Zhao, You-Fen Li and Shu-Feng Wang |
| Funding Agency and Grant Number |
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| Corresponding Author |
Shu-Feng Wang, MD, PhD, Department of General Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Yanta West Road 277, Xi’an 710061, Shaanxi Province, China. dawn@mail.xjtu.edu.cn |
| Key Words |
Docosahexaenoic acid; Gastric cancer; 5-fluorouracil; Cell line; Mitochondria |
| Core Tip |
We explored the synergistic anticancer properties of docosahexaenoic acid (DHA) and 5-fluorouracil (5-FU) against gastric cancer cells and the underlying mechanism. DHA and 5-FU alone or in combination could markedly suppress the proliferation of AGS cells in a significant time and dose-dependent manner. Co-administration of DHA with 5-FU resulted in a significantly larger shift toward the G0/G1 phase and a significant downregulation of the expression of mitochondrial electron transfer chain complexes in AGS cells. The associated mechanism may involve interference with energy production of AGS cells via downregulation of mitochondrial electron transfer chain complexes and cell cycle arrest in G0/G1 phase. |
| Publish Date |
2016-03-04 19:53 |
| Citation |
Gao K, Liang Q, Zhao ZH, Li YF, Wang SF. Synergistic anticancer properties of docosahexaenoic acid and 5-fluorouracil through interference with energy metabolism and cell cycle arrest in human gastric cancer cell line AGS cells. World J Gastroenterol 2016; 22(10): 2971-2980 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i10/2971.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i10.2971 |
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