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Articles Published Processes
4/12/2016 1:04:00 PM | Browse: 1352 | Download: 2220
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Received |
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2015-09-09 09:06 |
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Peer-Review Started |
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2015-09-10 12:32 |
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To Make the First Decision |
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2015-09-29 17:03 |
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Return for Revision |
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2015-10-05 13:53 |
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Revised |
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2015-10-26 16:32 |
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Second Decision |
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2015-11-27 08:33 |
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Accepted by Journal Editor-in-Chief |
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2015-11-29 03:51 |
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Accepted by Executive Editor-in-Chief |
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2015-12-08 17:18 |
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Articles in Press |
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2015-12-08 17:18 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2016-03-23 09:54 |
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Publish the Manuscript Online |
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2016-04-03 18:51 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Gallic acid induced apoptotic events in HCT-15 colon cancer cells
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Aruna Priyadharshni Subramanian, Saravana Kumar Jaganathan, Mahitosh Mandal, Eko Supriyanto and Ida Idayu Muhamad |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Research University Grant scheme with the Grant Vot |
Q.J130000.2509.10H13 (partly) |
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| Corresponding Author |
Dr. Saravana Kumar Jaganathan, IJN-UTM Cardiovascular Engineering Centre, Faculty of Biosciences and Medical Engineering, University Teknologi Malaysia, Johor Bahru 81310, Malaysia. jaganathaniitkgp@gmail.com |
| Key Words |
Gallic acid; Colon cancer; Apoptosis; Cell cycle; Reactive oxygen species; Lipid layer break |
| Core Tip |
This article describes the inhibitory effect of gallic acid (GA), against colon cancer cells. GA treatment suppressed the proliferation and colony formation of HCT-15 cells and the anti-cancerous effect of GA was found to follow reactive oxygen species dependent apoptosis. Early events associated with apoptosis like lipid layer breakage and fall in mitochondrial membrane potential were induced by GA treatment in HCT-15 cells along with cell cycle arrest. Further, morphological changes like membrane blebbing and cell shrinkage were seen in the colon cancer cells after GA. Therefore, our results propel the role of GA as a possible anticancer agent. |
| Publish Date |
2016-04-03 18:51 |
| Citation |
Subramanian AP, Jaganathan SK, Mandal M, Supriyanto E, Muhamad II. Gallic acid induced apoptotic events in HCT-15 colon cancer cells. World J Gastroenterol 2016; 22(15): 3952-3961 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i15/3952.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i15.3952 |
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