Publication Name	World Journal of Nephrology
Manuscript ID	22572
Country	United States

Received	2015-09-05 14:07
Peer-Review Started	2015-09-08 13:46
To Make the First Decision	2015-09-28 12:22
Return for Revision	2015-09-29 10:11
Revised	2015-10-12 00:21
Second Decision	2015-11-30 09:47
Accepted by Journal Editor-in-Chief	2015-12-01 12:56
Accepted by Executive Editor-in-Chief	2015-12-11 16:50
Articles in Press	2015-12-11 16:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-01-05 09:11
Publish the Manuscript Online	2016-01-06 20:46

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Physiology
Manuscript Type	Review
Article Title	How do kinases contribute to tonicity-dependent regulation of the transcription factor NFAT5?
Manuscript Source	Invited Manuscript
All Author List	Xiaoming Zhou
Funding Agency and Grant Number
Corresponding Author	Xiaoming Zhou, PhD, Division of Nephrology, Department of Medicine, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, United States. xiaoming.zhou@usuhs.edu
Key Words	Tonicity enhancer binding protein; Osmotic response element binding protein; Phosphorylation; Kidney; Urinary concentration; Signal transduction; Nephropathy; Hypertonicity; Hypotonicity
Core Tip	NFAT5 is critical for kidney functions. Its dis-regulation results in or is associated with the renal diseases and disorders. More than a dozen of kinases have been identified to contribute to tonicity-dependent regulation of NFAT5. The present review is focused on how these kinases regulate NFAT5 activity under the context of hypertonicity or hypotonicity. Understanding these regulatory mechanisms will have therapeutic implications. A precedent example is that recognition of the cyclosporine immunosuppressive effect resulted from inhibition of the phosphatase calcineurin-dependent activation of NFAT1 allows combination use of cyclosporine with other mechanistically different immunosuppressants to improve their therapeutic efficacy and reduce their side effects.
Publish Date	2016-01-06 20:46
Citation	Zhou X. How do kinases contribute to tonicity-dependent regulation of the transcription factor NFAT5? World J Nephrol 2016; 5(1): 20-32
URL	http://www.wjgnet.com/2220-6124/full/v5/i1/20.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i1.20

Full Article (PDF)	WJN-5-20.pdf
Full Article (Word)	WJN-5-20.doc
Manuscript File	22572-Review.docx
Answering Reviewers	22572-Answering reviewers.pdf
Audio Core Tip	22572-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22572-Conflict-of-interest statement.pdf
Copyright License Agreement	22572-Copyright assignment.pdf
Peer-review Report	22572-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22572-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22572-Scientific misconduct check.pdf
Scientific Editor Work List	22572-Scientific editor work list.pdf