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1/6/2016 8:46:00 PM | Browse: 1044 | Download: 1288
Publication Name World Journal of Nephrology
Manuscript ID 22572
Country/Territory United States
Received
2015-09-05 14:07
Peer-Review Started
2015-09-08 13:46
To Make the First Decision
2015-09-28 12:22
Return for Revision
2015-09-29 10:11
Revised
2015-10-12 00:21
Second Decision
2015-11-30 09:47
Accepted by Journal Editor-in-Chief
2015-12-01 12:56
Accepted by Company Editor-in-Chief
2015-12-11 16:50
Articles in Press
2015-12-11 16:50
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-01-05 09:11
Publish the Manuscript Online
2016-01-06 20:46
ISSN 2220-6124 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Physiology
Manuscript Type Review
Article Title How do kinases contribute to tonicity-dependent regulation of the transcription factor NFAT5?
Manuscript Source Invited Manuscript
All Author List Xiaoming Zhou
Funding Agency and Grant Number
Corresponding Author Xiaoming Zhou, PhD, Division of Nephrology, Department of Medicine, Uniformed Services University, 4301 Jones Bridge Road, Bethesda, MD 20814, United States. xiaoming.zhou@usuhs.edu
Key Words Tonicity enhancer binding protein; Osmotic response element binding protein; Phosphorylation; Kidney; Urinary concentration; Signal transduction; Nephropathy; Hypertonicity; Hypotonicity
Core Tip NFAT5 is critical for kidney functions. Its dis-regulation results in or is associated with the renal diseases and disorders. More than a dozen of kinases have been identified to contribute to tonicity-dependent regulation of NFAT5. The present review is focused on how these kinases regulate NFAT5 activity under the context of hypertonicity or hypotonicity. Understanding these regulatory mechanisms will have therapeutic implications. A precedent example is that recognition of the cyclosporine immunosuppressive effect resulted from inhibition of the phosphatase calcineurin-dependent activation of NFAT1 allows combination use of cyclosporine with other mechanistically different immunosuppressants to improve their therapeutic efficacy and reduce their side effects.
Publish Date 2016-01-06 20:46
Citation Zhou X. How do kinases contribute to tonicity-dependent regulation of the transcription factor NFAT5? World J Nephrol 2016; 5(1): 20-32
URL http://www.wjgnet.com/2220-6124/full/v5/i1/20.htm
DOI http://dx.doi.org/10.5527/wjn.v5.i1.20
Full Article (PDF) WJN-5-20.pdf
Full Article (Word) WJN-5-20.doc
Manuscript File 22572-Review.docx
Answering Reviewers 22572-Answering reviewers.pdf
Audio Core Tip 22572-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 22572-Conflict-of-interest statement.pdf
Copyright License Agreement 22572-Copyright assignment.pdf
Peer-review Report 22572-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 22572-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 22572-Scientific misconduct check.pdf
Scientific Editor Work List 22572-Scientific editor work list.pdf