Publication Name	World Journal of Gastroenterology
Manuscript ID	22624
Country	France

Received	2015-09-09 09:49
Peer-Review Started	2015-09-10 16:20
To Make the First Decision	2015-10-14 17:10
Return for Revision	2015-10-20 10:25
Revised	2015-11-19 18:20
Second Decision	2015-12-11 07:56
Accepted by Journal Editor-in-Chief	2015-12-11 08:11
Accepted by Executive Editor-in-Chief	2015-12-21 14:06
Articles in Press	2015-12-21 14:06
Publication Fee Transferred
Edit the Manuscript by Language Editor	2015-12-24 23:41
Typeset the Manuscript	2016-01-16 20:06
Publish the Manuscript Online	2016-01-23 17:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Cytomegalovirus and ulcerative colitis: Place of antiviral therapy
Manuscript Source	Invited Manuscript
All Author List	Sylvie Pillet, Bruno Pozzetto and Xavier Roblin
Funding Agency and Grant Number
Corresponding Author	Xavier Roblin, MD, PhD, Professor, Department of Gastroenterology, University Hospital of Saint-Etienne, 42055 Saint-Etienne Cedex 2, France. xavier.roblin@chu-st-etienne.fr
Key Words	Human cytomegalovirus; Ulcerative colitis; Inflammatory bowel disease; Ganciclovir; Viral load; Flare-up; Inflammation; Intestinal mucosa; Quantitative polymerase chain reaction
Core Tip	There is increasing evidence for the deleterious effect of in situ cytomegalovirus (CMV) reactivation in flare-ups of refractory ulcerative colitis. In patients aged > 30 years with a high density of infection in the colonic tissue, or with stigmata of severe disease associated with colonic markers of CMV reactivation (whatever the density of infection), treatment with ganciclovir is highly recommended, together with anti-tumor necrosis factor monoclonal antibody therapy in the absence of any contraindication to these drugs. For validating the present strategy based on our experience and the in-depth analysis of the available literature presented in this review, prospective randomized controlled studies are urgently needed.
Publish Date	2016-01-23 17:08
Citation	Pillet S, Pozzetto B, Roblin X. Cytomegalovirus and ulcerative colitis: Place of antiviral therapy. World J Gastroenterol 2016; 22(6): 2030-2045
URL	http://www.wjgnet.com/1007-9327/full/v22/i6/2030.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i6.2030

Full Article (PDF)	WJG-22-2030.pdf
Full Article (Word)	WJG-22-2030.doc
Manuscript File	22624-Review.docx
Answering Reviewers	22624-Answering reviewers.pdf
Audio Core Tip	22624-Audio core tip.wav
Copyright License Agreement	22624-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	22624-Language certificate.pdf
Peer-review Report	22624-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22624-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22624-Scientific misconduct check.pdf
Scientific Editor Work List	22624-Scientific editor work list.pdf