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Articles Published Processes
3/23/2016 4:26:00 PM | Browse: 1261 | Download: 2311
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Received |
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2015-09-11 08:45 |
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Peer-Review Started |
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2015-09-16 08:40 |
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To Make the First Decision |
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2015-11-05 11:03 |
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Return for Revision |
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2015-11-06 15:57 |
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Revised |
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2015-12-03 00:57 |
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Second Decision |
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2015-12-11 07:55 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2015-12-21 14:07 |
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Articles in Press |
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2015-12-21 14:07 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2016-02-27 01:42 |
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Typeset the Manuscript |
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2016-03-09 17:18 |
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Publish the Manuscript Online |
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2016-03-23 16:22 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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| Copyright |
© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Prospective Study |
| Article Title |
Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Radan Bruha, Marie Jachymova, Jaromir Petrtyl, Karel Dvorak, Martin Lenicek, Petr Urbanek, Tomislav Svestka and Libor Vitek |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Internal Grant Agency of the Czech Ministry of Health |
NT 12290/4 |
| Charles University in Prague |
SVV 260156/2015 |
| Czech Ministry of Health |
MZCR-RVO VFN64165 |
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| Corresponding Author |
Radan Bruha, MD, PhD, 4th Department of Internal Medicine, General University Hospital, U Nemocnice 2, 12808 Prague, Czech Republic. bruha@cesnet.cz
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| Key Words |
Cirrhosis; Complications of cirrhosis; Hepatic venous pressure gradient; Osteopontin; Portal hypertension; Prognosis; Survival prediction |
| Core Tip |
Data presented in our study are based on a 7-year follow-up interval with systematic hemodynamic evaluations of more than 150 cirrhotic patients. We report for the first time a close relationship between osteopontin (OPN) and portal hypertension. Our findings suggest that OPN in plasma could be a marker of clinically significant portal hypertension. Importantly, we found that OPN is a strong prognostic indicator in patients with liver cirrhosis; and, similar to hepatic venous pressure gradient (HVPG) value, it significantly determined survival probability. Moreover, the combination of HVPG and OPN increased the validity of prognosis.
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| Publish Date |
2016-03-23 16:22 |
| Citation |
Bruha R, Jachymova M, Petrtyl J, Dvorak K, Lenicek M, Urbanek P, Svestka T, Vitek L. Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis. World J Gastroenterol 2016; 22(12): 3441-3450 |
| URL |
http://www.wjgnet.com/1007-9327/full/v22/i12/3441.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v22.i12.3441 |
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