Publication Name	World Journal of Nephrology
Manuscript ID	22651
Country	United States

Received	2015-09-11 17:11
Peer-Review Started	2015-09-12 09:06
To Make the First Decision	2015-10-08 15:55
Return for Revision	2015-10-16 11:44
Revised	2015-10-27 09:02
Second Decision	2015-12-10 17:56
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2015-12-18 16:40
Articles in Press	2015-12-18 16:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-18 09:41
Publish the Manuscript Online	2016-03-01 14:46

ISSN	2220-6124 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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Category	Medicine, Research & Experimental
Manuscript Type	Minireviews
Article Title	Cooling dialysate during in-center hemodialysis: Beneficial and deleterious effects
Manuscript Source	Invited Manuscript
All Author List	Stephanie M Toth-Manikowski and Stephen M Sozio
Funding Agency and Grant Number
Corresponding Author	Stephanie M Toth-Manikowski, MD, Division of Nephrology, Department of Medicine, Johns Hopkins University School of Medicine, 1830 East Monument St., Suite 416, Baltimore, MD 21287, United States. stephanie.toth-manikowski@bmc.org
Key Words	Hemodialysis; Dialysate temperature; Cool dialysate; Intradialytic hypotension; Hypotensive episodes; Hemodynamic stability; Cool temperature dialysis
Core Tip	Cooled dialysate is commonly employed to reduce the incidence of intradialytic hypotension (IDH) in patients on chronic dialysis. The studies to date that have evaluated cooled dialysate are limited by small sample size and it has not become the standard of care for managing IDH. However, the small studies that exist are promising and suggest that cooling dialysate improves hemodynamic tolerability of dialysis, minimizes IDH, and exerts a protective effect over major organs including the heart and brain. More studies are needed to assess the long-term effects of cooling dialysate in this population.
Publish Date	2016-03-01 14:46
Citation	Toth-Manikowski SM, Sozio SM. Cooling dialysate during in-center hemodialysis: Beneficial and deleterious effects. World J Nephrol 2016; 5(2): 166-171
URL	http://www.wjgnet.com/2220-6124/full/v5/i2/166.htm
DOI	http://dx.doi.org/10.5527/wjn.v5.i2.166

Full Article (PDF)	WJN-5-166.pdf
Full Article (Word)	WJN-5-166.doc
Manuscript File	22651-Review.docx
Answering Reviewers	22651-Answering reviewers.pdf
Audio Core Tip	22651-Audio core tip.mp3
Conflict-of-Interest Disclosure Form	22651-Conflict-of-interest statement.pdf
Copyright License Agreement	22651-Copyright assignment.pdf
Peer-review Report	22651-Peer-review(s).pdf
Scientific Misconduct Check	22651-Scientific misconduct check.pdf
Scientific Editor Work List	22651-Scientific editor work list.pdf