Publication Name	World Journal of Gastroenterology
Manuscript ID	22654
Country	Italy

Received	2015-09-12 16:28
Peer-Review Started	2015-09-15 08:20
To Make the First Decision	2015-11-27 17:18
Return for Revision	2015-11-30 10:26
Revised	2015-12-14 19:47
Second Decision	2015-12-31 08:00
Accepted by Journal Editor-in-Chief	2015-12-31 20:51
Accepted by Executive Editor-in-Chief	2016-01-11 13:06
Articles in Press	2016-01-11 13:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2016-02-24 17:18
Publish the Manuscript Online	2016-03-14 08:44

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
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Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Epithelial turnover in duodenal familial adenomatous polyposis: A possible role for estrogen receptors?
Manuscript Source	Invited Manuscript
All Author List	Alfredo Di Leo, Gabriella Nesi, Mariabeatrice Principi, Domenico Piscitelli, Bruna Girardi, Maria Pricci, Giuseppe Losurdo, Andrea Iannone, Enzo Ierardi and Francesco Tonelli
Funding Agency and Grant Number
Corresponding Author	Enzo Ierardi, Professor, Gastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, Policlinico, Piazza Giulio Cesare, 70124 Bari, Italy. e.ierardi@virgilio.it
Key Words	Familial adenomatous polyposis; Duodenal cancer; Estrogen receptors; Immunohistochemistry; Confocal microscopy; Dysplasia
Core Tip	Familial adenomatous polyposis (FAP) is a genetically inherited disease featuring multiple colonic polyps, with possible duodenal involvement. No study investigating the relationship between estrogen receptors (ERs) and cellular turnover has previously been reported in duodenal FAP patient’s subset. In the present study we found that ER-β is strongly decreased in duodenal FAP carcinomas, in a multiple step fashion suggesting a putative anti-carcinogenic effect. ER-α shows the opposite trend. A possible ER-beta involvement in apoptosis is suggested by its co-expression with caspase-3. The modulation of hormonal influences in FAP duodenal tumorigenesis as a possible chemoprevention strategy may be a promising approach.
Publish Date	2016-03-14 08:44
Citation	Di Leo A, Nesi G, Principi M, Piscitelli D, Girardi B, Pricci M, Losurdo G, Iannone A, Ierardi E, Tonelli F. Epithelial turnover in duodenal familial adenomatous polyposis: A possible role for estrogen receptors? World J Gastroenterol 2016; 22(11): 3202-3211
URL	http://www.wjgnet.com/1007-9327/full/v22/i11/3202.htm
DOI	http://dx.doi.org/10.3748/wjg.v22.i11.3202

Full Article (PDF)	WJG-22-3202.pdf
Full Article (Word)	WJG-22-3202.doc
Manuscript File	22654-Review.doc
Answering Reviewers	22654-Answering reviewers.pdf
Audio Core Tip	22654-Audio core tip.mp3
Biostatistics Review Certificate	22654-Biostatistics statement.pdf
Clinical Trial Registration Statement	DeclarationOf_HelsinkiConformation_Statement_20150911185510.docx
Conflict-of-Interest Disclosure Form	22654-Conflict-of-interest statement.pdf
Copyright License Agreement	22654-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s)	Informed_Consent_Statement_20150911185357.docx
Institutional Review Board Approval Form or Document	22654-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate	22654-Language certificate.pdf
Peer-review Report	22654-Peer-review(s).pdf
Journal Editor-in-Chief Review Report	22654-Journal editor-in-chief review report.pdf
Scientific Misconduct Check	22654-Scientific misconduct check.pdf
Scientific Editor Work List	22654-Scientific editor work list.pdf