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3/14/2016 8:44:00 AM | Browse: 1079 | Download: 1874
Publication Name World Journal of Gastroenterology
Manuscript ID 22654
Country/Territory Italy
Received
2015-09-12 16:28
Peer-Review Started
2015-09-15 08:20
To Make the First Decision
2015-11-27 17:18
Return for Revision
2015-11-30 10:26
Revised
2015-12-14 19:47
Second Decision
2015-12-31 08:00
Accepted by Journal Editor-in-Chief
2015-12-31 20:51
Accepted by Company Editor-in-Chief
2016-01-11 13:06
Articles in Press
2016-01-11 13:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2016-02-24 17:18
Publish the Manuscript Online
2016-03-14 08:44
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Epithelial turnover in duodenal familial adenomatous polyposis: A possible role for estrogen receptors?
Manuscript Source Invited Manuscript
All Author List Alfredo Di Leo, Gabriella Nesi, Mariabeatrice Principi, Domenico Piscitelli, Bruna Girardi, Maria Pricci, Giuseppe Losurdo, Andrea Iannone, Enzo Ierardi and Francesco Tonelli
Funding Agency and Grant Number
Corresponding Author Enzo Ierardi, Professor, Gastroenterology Section, Department of Emergency and Organ Transplantation, University of Bari, Policlinico, Piazza Giulio Cesare, 70124 Bari, Italy. e.ierardi@virgilio.it
Key Words Familial adenomatous polyposis; Duodenal cancer; Estrogen receptors; Immunohistochemistry; Confocal microscopy; Dysplasia
Core Tip Familial adenomatous polyposis (FAP) is a genetically inherited disease featuring multiple colonic polyps, with possible duodenal involvement. No study investigating the relationship between estrogen receptors (ERs) and cellular turnover has previously been reported in duodenal FAP patient’s subset. In the present study we found that ER-β is strongly decreased in duodenal FAP carcinomas, in a multiple step fashion suggesting a putative anti-carcinogenic effect. ER-α shows the opposite trend. A possible ER-beta involvement in apoptosis is suggested by its co-expression with caspase-3. The modulation of hormonal influences in FAP duodenal tumorigenesis as a possible chemoprevention strategy may be a promising approach.
Publish Date 2016-03-14 08:44
Citation Di Leo A, Nesi G, Principi M, Piscitelli D, Girardi B, Pricci M, Losurdo G, Iannone A, Ierardi E, Tonelli F. Epithelial turnover in duodenal familial adenomatous polyposis: A possible role for estrogen receptors? World J Gastroenterol 2016; 22(11): 3202-3211
URL http://www.wjgnet.com/1007-9327/full/v22/i11/3202.htm
DOI http://dx.doi.org/10.3748/wjg.v22.i11.3202
Full Article (PDF) WJG-22-3202.pdf
Full Article (Word) WJG-22-3202.doc
Manuscript File 22654-Review.doc
Answering Reviewers 22654-Answering reviewers.pdf
Audio Core Tip 22654-Audio core tip.mp3
Biostatistics Review Certificate 22654-Biostatistics statement.pdf
Clinical Trial Registration Statement DeclarationOf_HelsinkiConformation_Statement_20150911185510.docx
Conflict-of-Interest Disclosure Form 22654-Conflict-of-interest statement.pdf
Copyright License Agreement 22654-Copyright assignment.pdf
Signed Informed Consent Form(s) or Document(s) Informed_Consent_Statement_20150911185357.docx
Institutional Review Board Approval Form or Document 22654-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 22654-Language certificate.pdf
Peer-review Report 22654-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 22654-Journal editor-in-chief review report.pdf
Scientific Misconduct Check 22654-Scientific misconduct check.pdf
Scientific Editor Work List 22654-Scientific editor work list.pdf